Document Detail


Characteristics and predictors of aortic plaques in patients with transient ischemic attacks and strokes.
MedLine Citation:
PMID:  14748204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To identify the prevalence and characteristics of aortic atherosclerotic plaque disease and its association with cerebrovascular risk factors in patients with cerebral ischemic events. BACKGROUND: Aortic atheroma is associated with ischemic stroke. Its characteristics, including morphology and distribution among different stroke subtypes, are not well described. METHOD: From July 2000 to August 2001, all patients evaluated by transesophageal echocardiography (TEE) with diagnoses of transient ischemic attacks (TIAs) and strokes were prospectively studied. Demographics, including age, gender, ethnicity, cerebrovascular risk factors, and stroke subtypes, were collected. RESULTS: Thoracic aortic atheromas (TAAs) were present in 141 of 237 patients (59%) (mean age = 59 +/- 14, 119 [50%] male). Mild plaque (< 2 mm) was present in 13 of 237 (5%), moderate plaque (2-4 mm) in 49 (21%), severe plaque (> or = 4 mm) in 79 (33%), and complex plaque in 64 (27%). Patients' ages (odds ratio [OR] = 1.05, confidence interval [CI] 1.03-1.08, P < .001), coronary artery disease (OR = 2.2, CI 1.02-4.8, P < .042), and patent foramen ovale (PFO) (OR = 0.39, CI 0.22-0.70, P < .002) were associated with the severity and complexity of aortic plaque. In multivariate analysis, age (OR = 1.06, CI 1.03-1.08, P < .001) and the presence of PFO (OR = 0.35, CI 0.18-0.65, P < .001) continued to be significant to the severity and complexity of aortic atheroma. Gender, history of stroke, hypertension, diabetes mellitus, hyperlipidemia, and history of smoking were not associated with TAA. CONCLUSION: One third of TAA plaques are severe and complex in nature and more frequently present in the descending aorta and the arch of the aorta than in the ascending aorta. TEE should be considered for the early detection and treatment of TAA in patients without identified causes of stroke.
Authors:
Abutaher M Yahia; Jawad F Kirmani; Andrew R Xavier; Aasma Shaukat; Adnan I Qureshi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  14     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-29     Completed Date:  2004-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-22     Citation Subset:  IM    
Affiliation:
Division of Neurocardiology, Department of Neurology and Neurosciences, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB H-506, Newark, NJ 07103-2757, USA. yahia25@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aorta, Thoracic / ultrasonography
Aortic Diseases / complications,  ultrasonography*
Arteriosclerosis / complications,  ultrasonography*
Echocardiography, Transesophageal
Female
Humans
Ischemic Attack, Transient / etiology*
Male
Middle Aged
Prospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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