Document Detail


Characteristics of potential drug-related problems among oncology patients.
MedLine Citation:
PMID:  23283597     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background Oncology patients are more at risk for drug related problems because of treatment with (combinations of) anticancer drugs, as they have a higher risk for organ failure or altered metabolism with progression of their disease. Objective The aim of this study was to characterize and to evaluate the frequency of potential drug related problems (pDRPs) among oncology patients. Setting Outpatient- and day-care centres for Internal and Pulmonary Medicine at the Deventer Hospital, Deventer, The Netherlands. Method A prospective, descriptive, observational study was carried out from March 2010 to March 2011 at the Deventer Hospital, Deventer, The Netherlands. All patients older than 18 years receiving anticancer drugs prescribed by an internal medicineoncologist or pulmonologist-oncologist were included. Main outcome measure The primary outcome was the number and type of pDRPs according to Dutch guidelines. Results Among 546 patients with cancer, 952 pDRPs were identified, of which 474 were oncology-related. These were mainly drug interactions (IA) (246 IA in 157 patients) and potential contraindications (pCI) (201 pCI in 143 patients). Conclusion Most identified pDRPs in cancer patients were IAs and pCIs and involved corticosteroids. The most frequently occurring oncology-related IAs were classified as minor or moderate levels of severity.
Authors:
Arjan Bulsink; Alex L T Imholz; Jacobus R B J Brouwers; Frank G A Jansman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  International journal of clinical pharmacy     Volume:  -     ISSN:  2210-7711     ISO Abbreviation:  Int J Clin Pharm     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101554912     Medline TA:  Int J Clin Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Clinical Pharmacy (E3.019), Deventer Hospital, PO-Box 5001, 7400 GC, Deventer, The Netherlands, a.bulsink@skbwinterswijk.nl.
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