Document Detail


Characteristics of postural stability in patients with aminoglycoside toxicity.
MedLine Citation:
PMID:  8186864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postural stability in patients with bilateral vestibular deficits from aminoglycoside toxicity was characterized by examining their ability to use different sensory cues to maintain balance and by recording their automatic postural responses to sudden translational and rotational (pitch) perturbations of the support surface. We found our patients had increased sway on sensory tests in which either visual or somatosensory cues were altered and were unable to maintain their balance when both visual and somatosensory cues were altered compared to age-matched normal subjects. The amount of vestibular loss, as inferred from the VOR Tc, accounted for a significant amount of A-P sway on test 4 in which somatosensory cues were altered. The frequency response of anterior-posterior sway in the BVL group suggests that they use more hip movements than do normal subjects to maintain postural stability. The responses of BVL patients to sudden translations of the support surface did not differ from those of normal subjects. More BVL patients lost their balance, however, on the initial trial of the toes-up rotational perturbation of the support surface than did normal subjects.
Authors:
S J Herdman; A L Sandusky; T C Hain; D S Zee; R J Tusa
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vestibular research : equilibrium & orientation     Volume:  4     ISSN:  0957-4271     ISO Abbreviation:  J Vestib Res     Publication Date:  1994  
Date Detail:
Created Date:  1994-06-23     Completed Date:  1994-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9104163     Medline TA:  J Vestib Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-80     Citation Subset:  IM; S    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aminoglycosides
Anti-Bacterial Agents / adverse effects*
Female
Humans
Male
Middle Aged
Postural Balance*
Posture / physiology*
Psychomotor Performance
Reflex, Vestibulo-Ocular
Sensation Disorders / etiology*,  physiopathology
Vestibular Diseases / chemically induced*,  complications,  physiopathology
Vestibular Function Tests
Grant Support
ID/Acronym/Agency:
NIDCD DC00032/DC/NIDCD NIH HHS; R01-EY05505/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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