| Characteristics of periodontal microflora in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 15898935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Periodontitis has been linked to increased risk of cardiovascular diseases. Systemic reactions associated with cardiovascular events may depend on characteristics of the subgingival microflora in periodontitis. Our objectives were to compare the numbers of cultivable bacteria, composition of subgingival microflora and clonal distribution of Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) in two groups of patients with generalized chronic periodontitis (GCP), one with an acute myocardial infarction (AMI-GCP) and the other one without AMI (non-AMI-GCP). METHODS: In all, 150 dentate individuals were screened for suitability to this study. Subgingival bacterial samples were collected from 11 AMI-GCP and 11 non-AMI-GCP patients who had been selected using strict inclusion criteria in an attempt to exclude confounding factors and to increase comparability of periodontal conditions by matching for periodontal probing depths and attachment levels. Culture methods were used to determine the total viable counts and occurrence and proportions of six periodontal bacterial species and yeasts. Polymerase chain reaction (PCR) technique was used to detect A. actinomycetemcomitans and Porphyromonas gingivalis (P. gingivalis). Intraspecies characterization of A. actinomycetemcomitans included serotyping and genotyping. RESULTS: The mean proportions of P. gingivalis (P = 0.05) and Tannerella forsythensis (T. forsythensis) (P = 0.01) were significantly lower, but the numbers of Micromonas micros (M. micros) and A. actinomycetemcomitans were up to nine times higher and the mean total number of cultivable bacteria per sample higher (P <0.01) in AMI-GCP than in non-AMI-GCP. CONCLUSION: The findings that no target subgingival species were overrepresented but the total bacterial number was higher in AMI-GCP than non-AMI-GCP patients may provide support to the hypothesis that elevated numbers of bacteria in close vicinity to sterile parenteral area present a risk for systemic health. |
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Authors:
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Başak Doĝan; Eralp Buduneli; Gülnur Emingil; Gül Atilla; Azem Akilli; Johanna Antinheimo; Laura Lakio; Sirkka Asikainen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of periodontology Volume: 76 ISSN: 0022-3492 ISO Abbreviation: J. Periodontol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-18 Completed Date: 2005-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 740-8 Citation Subset: D; IM |
Affiliation:
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Department of Basic Health Sciences, Faculty of Health Education, University of Marmara, Istanbul, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actinobacillus actinomycetemcomitans
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isolation & purification* Adult Aged Chi-Square Distribution Female Genotype Humans Male Middle Aged Myocardial Infarction / microbiology* Periodontal Pocket / microbiology Periodontitis / microbiology* Serotyping Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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