Document Detail

Characteristics of patients with spinal tuberculosis: seven-year experience of a teaching hospital in Southwest China.
MedLine Citation:
PMID:  22358176     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to investigate the characteristics of patients managed for spinal tuberculosis at the orthopaedics department of a teaching hospital in Chongqing, China, between 2004 and 2010.
METHODS: The study used a retrospective chart review. The epidemiology, clinical features, laboratory test results, imaging study findings, and treatment methods were recorded.
RESULTS: The annual incidence of spinal tuberculosis was stable throughout the study period. There were 284 patients, 147 women and 137 men, with a mean age of 38.2 years. The majority of the lesions involved the thoracic spine (45.3%), followed by the lumbar spine (45.0%). Multiple level skip lesions were seen in 5.6% of cases. The erythrocyte sedimentation rate was normal in 26.8% of patients. The C-reactive protein (CRP) was normal in 30.2% of patients. Type A and type O were the most common blood types. Neurological involvement was seen in 21.8% of patients. Concomitant tuberculosis of the lung was seen in 73 (25.7%). The patients with middle school education and above account for 60.4% (102/169) in rural patients and 68.7% (79/115) in urban patients. Mean time from symptom onset to diagnosis was 18.0 months (range, three days to 360 months), and there was a significant difference between the rural patients (23.0 months) and the urban patients (10.7 months) (p=0.001, t=-3.300). Surgical treatment was performed in 233 patients (82.0%). The preferred surgical procedure was radical anterior debridement, bone grafting and internal fixation (132 patients, 46.5%). There were 13 patients (4.2%) with anti-tuberculous chemotherapy drug allergy or toxicity, streptomycin anaphylaxis and toxicity in 12, and isoniazide anaphylaxis and toxicity in one. No mortality was related to spinal TB.
CONCLUSION: The annual incidence of spinal tuberculosis remained unchanged throughout the study period and most of the patients did not pay much attention to the disease and received timely treatment. Thus, we should strengthen the census and treatment of spinal tuberculosis in Southwest China.
Hongwei Wang; Changqing Li; Jian Wang; Zhengfeng Zhang; Yue Zhou
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Publication Detail:
Type:  Journal Article     Date:  2012-02-23
Journal Detail:
Title:  International orthopaedics     Volume:  36     ISSN:  1432-5195     ISO Abbreviation:  Int Orthop     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-10-31     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1429-34     Citation Subset:  IM    
Department of Orthopedics, Xinqiao Hospital, The Third Military Medical University, Xinqiao Street, Chongqing, 400037, People's Republic of China.
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MeSH Terms
Antitubercular Agents / therapeutic use*
Bone Transplantation / methods
China / epidemiology
Combined Modality Therapy
Debridement / methods
Fracture Fixation, Internal / methods
Hospitals, Teaching*
Orthopedics / education
Retrospective Studies
Risk Factors
Surgical Procedures, Operative / methods*
Tuberculosis, Spinal / epidemiology,  pathology*,  therapy
Reg. No./Substance:
0/Antitubercular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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