Document Detail

Characteristics of patients with a localized retinal nerve fiber layer defect and normal optic disc appearance.
MedLine Citation:
PMID:  23037909     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the characteristics of patients with a localized retinal nerve fiber layer (RNFL) defect and normal optic disc appearance compared with normal tension glaucoma (NTG) patients.
METHODS: A total of 40 patients with an unchanged RNFL defect for more than 5 years and normal optic disc appearance, who were presumed as non-glaucomatous patients, were enrolled (group A). We recruited 40 age-matched patients with NTG (group B). On the RNFL photographs, we evaluated angles of RNFL defects. Angle α and β were the angles made by the line 'L' from the center of the fovea to the disc center and the lines 'A' and 'B' from the disc center to the disc margin where the proximal and the distal border of the defect met, respectively. Angle θ was the angular width of the defect. Angle γ was the angle made by lines 'L' and 'R', which divides angle θ into a 2 :1 ratio from line 'A' to line 'B'. We compared systemic diseases, baseline IOP, and location and angles of the RNFL defects between the two groups.
RESULTS: Systemic diseases and superotemporal RNFL defects in group A were significantly greater than those in group B (P<0.001). Angle α was greater in group A, but angle β, θ, and γ were smaller in group A (P<0.05).
CONCLUSION: If the patients with a superotemporal RNFL defect and normal optic disc appearance had systemic diseases and distal borders of the defects are closer to the macula, glaucoma is less likely.
J Lee; J Kim; C Kee
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-10-05
Journal Detail:
Title:  Eye (London, England)     Volume:  26     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-15     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1473-8     Citation Subset:  IM    
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Follow-Up Studies
Intraocular Pressure
Low Tension Glaucoma / diagnosis*
Middle Aged
Nerve Fibers / pathology*
Optic Disk / pathology*
Optic Nerve Diseases / diagnosis*
Retinal Ganglion Cells / pathology*
Retrospective Studies
Tonometry, Ocular
Vision Disorders / diagnosis
Visual Field Tests
Visual Fields

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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