Document Detail

Characteristics of patients resistant to antihypertensive drug therapy.
MedLine Citation:
PMID:  2040868     Owner:  NLM     Status:  MEDLINE    
In order to determine the features that characterize refractory hypertension (RH), patients aged less than 65 years in a hypertension clinic were screened. Thirty-six patients on triple drug therapy with a supine diastolic blood pressure (DBP) of greater than or equal to 5 mmHg above an identified target pressure (90-100 mmHg), or a systolic blood pressure (SBP) greater than or equal to 170 mmHg for the last 6 months (greater than or equal to 3 measurements) underwent a thorough clinical investigation. The frequency of renal artery stenosis (RAS) in the RH patients was 30%. The non-RAS patients had a low occupational status, 76% being either manual workers or unskilled non-manual workers (reference group: 42%; P less than 0.01). They were more obese (body mass index (BMI) 28.8 vs. 25.8; P less than 0.01), and had a longer duration of hypertensive disease. RH patients had a higher prevalence of non-insulin-dependent diabetes mellitus (18 vs. 6%; P less than 0.05), and showed a higher prevalence of nervous complaints and mental distress (44% vs. 12%; P less than 0.001) and musculo-skeletal pain (39% vs. 7%: P less than 0.001). It is suggested that refractory hypertension should be investigated and treated bearing psychosocial factors in mind, concurrently with a screening for secondary hypertension.
H Isaksson; M Danielsson; G Rosenhamer; J C Konarski-Svensson; J Ostergren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  229     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-07-11     Completed Date:  1991-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  421-6     Citation Subset:  IM    
Department of Internal Medicine I, Södersjukhuset, Stockholm, Sweden.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Body Mass Index
Drug Resistance
Hypertension / complications,  drug therapy*,  physiopathology
Hypertension, Renovascular / physiopathology
Middle Aged
Socioeconomic Factors
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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