| Characteristics of patients resistant to antihypertensive drug therapy. | |
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MedLine Citation:
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PMID: 2040868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to determine the features that characterize refractory hypertension (RH), patients aged less than 65 years in a hypertension clinic were screened. Thirty-six patients on triple drug therapy with a supine diastolic blood pressure (DBP) of greater than or equal to 5 mmHg above an identified target pressure (90-100 mmHg), or a systolic blood pressure (SBP) greater than or equal to 170 mmHg for the last 6 months (greater than or equal to 3 measurements) underwent a thorough clinical investigation. The frequency of renal artery stenosis (RAS) in the RH patients was 30%. The non-RAS patients had a low occupational status, 76% being either manual workers or unskilled non-manual workers (reference group: 42%; P less than 0.01). They were more obese (body mass index (BMI) 28.8 vs. 25.8; P less than 0.01), and had a longer duration of hypertensive disease. RH patients had a higher prevalence of non-insulin-dependent diabetes mellitus (18 vs. 6%; P less than 0.05), and showed a higher prevalence of nervous complaints and mental distress (44% vs. 12%; P less than 0.001) and musculo-skeletal pain (39% vs. 7%: P less than 0.001). It is suggested that refractory hypertension should be investigated and treated bearing psychosocial factors in mind, concurrently with a screening for secondary hypertension. |
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Authors:
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H Isaksson; M Danielsson; G Rosenhamer; J C Konarski-Svensson; J Ostergren |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of internal medicine Volume: 229 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-07-11 Completed Date: 1991-07-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 421-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, Södersjukhuset, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Body Mass Index Drug Resistance Female Humans Hypertension / complications, drug therapy*, physiopathology Hypertension, Renovascular / physiopathology Male Middle Aged Socioeconomic Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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