Document Detail


Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudy.
MedLine Citation:
PMID:  19237684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our understanding of the growing population of revascularized patients with hypertension is limited. We retrospectively analyzed the International Verapamil SR-Trandolapril Study, which randomized coronary artery disease patients with hypertension to either verapamil SR- or atenolol-based treatment strategies, focusing on characteristics and outcomes of 6166 previously revascularized patients compared with 16 410 nonrevascularized patients. Revascularized patients had a history of coronary artery bypass grafting (45.2%), percutaneous coronary intervention (42.1%), or both (12.8%). Compared with nonrevascularized patients, revascularized patients at baseline demonstrated a higher prevalence of coronary artery disease risk factors and risk conditions (P<0.001). This higher prevalence was the principal cause of a higher incidence of primary outcome (death, nonfatal myocardial infarction, or nonfatal stroke) among revascularized patients (14.2% versus 8.5% for nonrevascularized patients; P<0.001). However, both patient groups demonstrated a relatively low incidence of subsequent revascularization (5.1% versus 1.5% respectively; P<0.0001). Associations between adjusted hazard ratio for primary outcome and follow-up blood pressure appeared "J shaped" for both patient groups. Because, as a group, revascularized patients with hypertension had worse outcomes compared with nonrevascularized patients, management of blood pressure to a specific target in future studies could result in improved outcomes.
Authors:
Scott J Denardo; Franz H Messerli; Efrain Gaxiola; Juan M Aranda; Rhonda M Cooper-Dehoff; Eileen M Handberg; Yan Gong; Annette Champion; Qian Zhou; Carl J Pepine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-23
Journal Detail:
Title:  Hypertension     Volume:  53     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-04-22     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  624-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Balloon, Coronary
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use
Coronary Artery Bypass
Coronary Artery Disease* / mortality,  surgery,  therapy
Female
Humans
Hypertension / drug therapy*,  mortality*
Incidence
Indoles / therapeutic use*
Male
Middle Aged
Prevalence
Randomized Controlled Trials as Topic
Retrospective Studies
Risk Factors
Survival Analysis
Treatment Outcome
Verapamil / therapeutic use*
Grant Support
ID/Acronym/Agency:
K23 HL086558/HL/NHLBI NIH HHS; K23 HL086558-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Indoles; 87679-37-6/trandolapril; CJ0O37KU29/Verapamil
Comments/Corrections

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