| Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudy. | |
| | |
MedLine Citation:
|
PMID: 19237684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Our understanding of the growing population of revascularized patients with hypertension is limited. We retrospectively analyzed the International Verapamil SR-Trandolapril Study, which randomized coronary artery disease patients with hypertension to either verapamil SR- or atenolol-based treatment strategies, focusing on characteristics and outcomes of 6166 previously revascularized patients compared with 16 410 nonrevascularized patients. Revascularized patients had a history of coronary artery bypass grafting (45.2%), percutaneous coronary intervention (42.1%), or both (12.8%). Compared with nonrevascularized patients, revascularized patients at baseline demonstrated a higher prevalence of coronary artery disease risk factors and risk conditions (P<0.001). This higher prevalence was the principal cause of a higher incidence of primary outcome (death, nonfatal myocardial infarction, or nonfatal stroke) among revascularized patients (14.2% versus 8.5% for nonrevascularized patients; P<0.001). However, both patient groups demonstrated a relatively low incidence of subsequent revascularization (5.1% versus 1.5% respectively; P<0.0001). Associations between adjusted hazard ratio for primary outcome and follow-up blood pressure appeared "J shaped" for both patient groups. Because, as a group, revascularized patients with hypertension had worse outcomes compared with nonrevascularized patients, management of blood pressure to a specific target in future studies could result in improved outcomes. |
| | |
Authors:
|
Scott J Denardo; Franz H Messerli; Efrain Gaxiola; Juan M Aranda; Rhonda M Cooper-Dehoff; Eileen M Handberg; Yan Gong; Annette Champion; Qian Zhou; Carl J Pepine |
Related Documents
:
|
19059264 - Suppression of inflammatory signaling in monocytes from patients with coronary artery d... 15193684 - Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome ... 2632824 - Clinical characteristics of sudden cardiac death in patients with vasospastic angina. 8677864 - Relation of patient characteristics to cardiac ischemia during daily life activity (an ... 20064744 - Cheyne-stokes respiration in heart failure: cycle length is dependent on left ventricul... 6737574 - Incontinence, intermittent self-catheterization and the artificial genitourinary sphinc... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-23 |
Journal Detail:
|
Title: Hypertension Volume: 53 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-20 Completed Date: 2009-04-22 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
|
Languages: eng Pagination: 624-30 Citation Subset: IM |
Affiliation:
|
Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL 32610, USA. scott.denardo@medicine.ufl.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Balloon, Coronary Antihypertensive Agents / therapeutic use Blood Pressure / drug effects Calcium Channel Blockers / therapeutic use Coronary Artery Bypass Coronary Artery Disease* / mortality, surgery, therapy Female Humans Hypertension / drug therapy*, mortality* Incidence Indoles / therapeutic use* Male Middle Aged Prevalence Randomized Controlled Trials as Topic Retrospective Studies Risk Factors Survival Analysis Treatment Outcome Verapamil / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
|
K23 HL086558-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Indoles; 52-53-9/Verapamil; 87679-37-6/trandolapril |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A simplified approach to the treatment of uncomplicated hypertension: a cluster randomized, controll...
Next Document: Alternative induction of meiotic recombination from single-base lesions of DNA deaminases.