Document Detail


Characteristics and outcomes of double outlet left ventricle.
MedLine Citation:
PMID:  21106011     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Double outlet left ventricle (DOLV) is a rare cardiac malformation in which both great arteries originate from the morphological left ventricle. There are limited data regarding the anatomical spectrum, characteristics and outcomes of DOLV.
METHODS: All patients with DOLV between 1960 and 2008 were identified. Patients' presentation, anatomy, surgical history, and outcomes were recorded. Kaplan-Meier estimates were used to describe time-related survival and freedom from surgical intervention.
RESULTS: There were 19 patients with DOLV during the study period, 14 of whom were male (74%). Median age at presentation was 2 days (birth--5.5 years). The most prominent associated cardiac morphologies (in addition to DOLV) were atrial septal defects (14, 74%), ventricular septal defects (13, 68%), right ventricular hypoplasia (12, 63%), and patent ductus arteriosus (15, 80%). At presentation, nine patients (47%) were cyanosed, nine (42%) had cardiomegaly, and all had some degree of right ventricular dysfunction. Of the 19 patients, seven underwent biventricular repairs, nine underwent univentricular palliations, one had only palliative care, and two were seen for consultation only. There were six deaths in this series, five were cardiac in nature (one due to genetic syndrome). Five-year survival after presentation for both biventricular and univentricular repairs was 70-75% (P= 0.80). Most surviving patients had residual cardiac abnormalities at last follow-up despite surgical repair.
DISCUSSION: DOLV is a rare cardiac malformation associated with high mortality and guarded outcomes from residual lesions.
Authors:
Carolin Imai-Compton; Maryam Elmi; Cedric Manlhiot; Alejandro A Floh; Fraser Golding; William G Williams; Brian W McCrindle
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital heart disease     Volume:  5     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-25     Completed Date:  2011-03-10     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  532-6     Citation Subset:  IM    
Copyright Information:
© 2010 Copyright the Authors. Congenital Heart Disease © 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Pediatrics, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple*
Aorta / abnormalities*,  surgery
Cardiac Surgical Procedures
Child
Child, Preschool
Female
Heart Defects, Congenital* / mortality,  pathology,  physiopathology,  surgery
Heart Ventricles / abnormalities*,  physiopathology,  surgery
Humans
Infant
Infant, Newborn
Kaplan-Meier Estimate
Male
Ontario
Palliative Care
Pulmonary Artery / abnormalities*,  surgery
Retrospective Studies
Survival Rate
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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