Document Detail


Characteristics and outcome of myelodysplastic syndromes (MDS) with isolated 20q deletion: A report on 62 cases.
MedLine Citation:
PMID:  21396711     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Isolated 20q deletion is common in MDS and considered of good prognosis, but no large series have been reported. We compared characteristics of 62 MDS patients with isolated del 20q, 36 patients with del 20q and other cytogenetic abnormalities, and 1335 MDS patients without del20q. Significant differences between MDS with isolated del 20q and patients without del 20q were lower platelet count (mean 144 vs. 196 G/l, p=0.005), lower marrow blast count (mean 3.9% vs. 5.6%, p=0.0008), and higher reticulocyte count (mean 72.5 vs. 51.7 G/l, p=0.04). Ten (16%) patients with isolated del 20q had Hb>12g/dl and platelets <100 G/l, compared to 7.3% of patients without del 20q (p=0.025). Review of marrow slides of those 10 patients showed that could be readily identified as MDS prior to cytogenetics. Fourteen percent of patients with isolated del 20q progressed to AML compared to 11% with one and 24% with several additional abnormalities. Median survival was 54 months in patients with isolated del 20q, not reached and 12 months for del 20q with one and several additional abnormalities, respectively (p=0.035) confirming the favorable prognosis of del 20q without complex abnormalities.
Authors:
Thorsten Braun; Stéphane de Botton; Anne-Laure Taksin; Sophie Park; Odile Beyne-Rauzy; Valérie Coiteux; Rosa Sapena; Anne Lazareth; Geneviève Leroux; Khaled Guenda; Bruno Cassinat; Michaela Fontenay; Norbert Vey; Agnès Guerci; François Dreyfus; Dominique Bordessoule; Aspasia Stamatoullas; Sylvie Castaigne; Christine Terré; Virginie Eclache; Pierre Fenaux; Lionel Adès
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-9
Journal Detail:
Title:  Leukemia research     Volume:  -     ISSN:  1873-5835     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Service d'Hématologie Clinique, University Paris XIII, Bobigny, France.
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