| Characteristics of orbital multiple myeloma: a case report and literature review. | |
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MedLine Citation:
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PMID: 19709708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple myeloma is a plasma cell malignancy that destroys skeletal, renal, and neurological function. Orbital involvement is rare, but has been considered an initial presentation for the malignancy. Furthermore, an association between the subtype of multiple myeloma and the likelihood of orbital infiltration has been suggested. We present a case of an orbital mass that was a recurrence of multiple myeloma. A literature search was performed to evaluate the presentation characteristics of orbital multiple myeloma, plasmacytoma and primary (or solitary) extramedullary plasmacytoma. Past reports were analyzed for age, sex, symptoms at presentation, time from symptom onset to presentation, prior diagnosis before presentation for orbital symptoms, radiological characteristics, immunoglobulin subtype, and survival times. Less than half of published cases had orbital multiple myeloma as the primary presentation. Proptosis is the major presenting sign of orbital multiple myeloma, and radiological evaluation shows that the majority of masses originate in the superotemporal quadrant. The dominant immunoglobulin subtype was IgG. |
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Authors:
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Cat N Burkat; Jeremy J Van Buren; Mark J Lucarelli |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-08-25 |
Journal Detail:
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Title: Survey of ophthalmology Volume: 54 ISSN: 1879-3304 ISO Abbreviation: Surv Ophthalmol Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-10-12 Completed Date: 2009-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404551 Medline TA: Surv Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 697-704 Citation Subset: IM |
Affiliation:
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Oculoplastics Service, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53792-3284, USA. catburkat@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Agents / therapeutic use Combined Modality Therapy Humans Immunoglobulin A / blood Immunoglobulin kappa-Chains / analysis Male Multiple Myeloma / pathology*, radiography, therapy Ophthalmologic Surgical Procedures Orbital Neoplasms / pathology*, radiography, therapy Retrospective Studies Tomography, X-Ray Computed Visual Acuity |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Immunoglobulin A; 0/Immunoglobulin kappa-Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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