Document Detail

Characteristics of nitrogen metabolism in rats with thioacetamide-induced liver cirrhosis.
MedLine Citation:
PMID:  10433379     Owner:  NLM     Status:  MEDLINE    
Female Sprague-Dawley rats were given 0.03% thioacetamide (TAA) in their drinking water daily for 4 or 12 weeks, and were then given normal water for 4 weeks after the end of a 12-week TAA treatment to investigate amino acid metabolism. In the malnourished precirrhotic stage (stage 1) and the malnourished cirrhotic stage (stage 2), the aromatic amino acids (AAA), Glu, Asp, Orn, Arg and Cit increased, and the branched-chain amino acids (BCAA) decreased slightly. Because these changes normalized in the well-nourished cirrhotic stage (stage 3), they might have resulted from impairment of hepatocytes and malnutrition. The net uptake of BCAA into the liver increased in stage 2, but the AAA uptake did not exceed that in normal controls. Portal venous plasma AAA increased to the same level as arterial plasma AAA. These results suggest that the decrease in BCAA was partially due to liver uptake and that the increase in AAA was induced by reduction of liver uptake and overproduction in extrahepatic tissues. The liver contents of BCAA and AAA were unchanged in all stages, so were fully utilized in the impaired liver. The increases in Glu, Asp, Orn and Cit might have resulted from overproduction in the liver, because these contents of the liver increased in stage 2. In conclusion, the changes in amino acid metabolism in rats with cirrhosis induced by TAA closely resemble those seen in human liver cirrhosis.
S Masumi; M Moriyama; Y Kannan; M Ohta; O Koshitani; O Sawamoto; S Toyoshima; K Ishikawa; M Miyoshi; T Sugano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  132     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-08-19     Completed Date:  1999-08-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  155-66     Citation Subset:  IM    
Department of Veterinary Physiology, College of Agriculture, Osaka Prefecture University, Sakai, Japan.
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MeSH Terms
Amino Acids / metabolism
Body Weight / drug effects
Eating / drug effects
Liver / metabolism,  pathology
Liver Circulation / drug effects
Liver Cirrhosis, Experimental / chemically induced,  metabolism*
Nitrogen / metabolism*
Rats, Sprague-Dawley
Thioacetamide / toxicity*
Reg. No./Substance:
0/Amino Acids; 62-55-5/Thioacetamide; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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