Document Detail


Characteristics of a nickel-albumin binding assay for assessment of myocardial ischaemia.
MedLine Citation:
PMID:  20384453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to describe a method to measure ischaemia-induced alterations of the binding capacity of serum albumin to exogenous nickel. METHODS: We measured the levels of cardiac troponin I (cTnI), serum albumin, ischaemia-modified albumin (IMA) measured by a cobalt-albumin binding assay (CABA), and a nickel-albumin binding assay (NABA) in the following groups: myocardial infarction (n = 32) and non-ischaemic chest pain (n = 64). RESULTS: IMA, cTnI and NABA levels were higher in the myocardial infarction group. NABA presented a higher ability to discriminate myocardial ischaemia than CABA. CONCLUSIONS: Patients with myocardial infarction have reduced nickel binding to human serum albumin, and NABA may have an important role as an early marker of myocardial ischaemia.
Authors:
Sandra Huber da Silva; Bruna dos Santos Hausen; Dievan Bisognin da Silva; Aline Minuzzi Becker; Marli Matiko Anraku de Campos; Marta Maria Medeiros Frescura Duarte; Rafael Noal Moresco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  15     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-7     Citation Subset:  IM    
Affiliation:
Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cobalt / metabolism
Female
Humans
Male
Middle Aged
Myocardial Ischemia / diagnosis*,  metabolism
Nickel / metabolism*
ROC Curve
Serum Albumin / metabolism*
Troponin I / blood
Troponin T / blood
Chemical
Reg. No./Substance:
0/Serum Albumin; 0/Troponin I; 0/Troponin T; 7440-02-0/Nickel; 7440-48-4/Cobalt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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