| Characteristics of insulin resistance and insulin secretory capacity in Korean subjects with IFG and IGT. | |
| | |
MedLine Citation:
|
PMID: 20605249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Both IFG and IGT are prediabetic conditions that can progress to type 2 DM. However, previous studies have shown that these are not identical. This study was conducted on 307 drug naïve prediabetic adults who did not meet the diagnostic criteria for diabetes based on the OGTT. According to the OGTT, the subjects were divided into isolated IFG (i-IFG), isolated IGT (i-IGT), and combined glucose intolerance (CGI) group. We also measured insulin resistance indices (HOMA-IR, WBISI), an insulin secretion indices (insulinogenic index [IGI], AUC I/G(0-120), disposition index [DI]), and compared each of the three groups. The OGTT measurements showed that 87 subjects were diagnosed with i-IFG, 75 subjects had i-IGT, and 145 subjects had CGI. With respect to the insulin resistance indices, HOMA-IR and WBISI were not significantly different. However, insulin secretory capacity, the IGI and DI were significantly higher for the i-IFG group. Moreover, after confounders were adjusted, HOMA-IR, IGI, AUC I/G(0-120), and the DI were significantly higher for the i-IFG group and WBISI was significantly higher for the i-IGT group. These results demonstrate that the pathogenesis of IFG is more closely associated with insulin resistance, and the pathogenesis of IGT is more closely associated with impaired insulin secretion. |
| | |
Authors:
|
Sang Youl Rhee; Jeong-taek Woo; Suk Chon; You Cheol Hwang; Seungjoon Oh; Kyu Jeung Ahn; Ho Yeon Chung; Sung Woon Kim; Jin-Woo Kim; Young Seol Kim |
Related Documents
:
|
11391229 - Beta-cell dysfunction rather than insulin resistance is the main contributing factor fo... 18398809 - Beneficial effects of strategies for primary prevention of diabetes on cardiovascular r... 8201959 - Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impa... 19587369 - Changes in insulin secretion and insulin sensitivity in relation to the glycemic outcom... 20627649 - A large proportion of prediabetes and diabetes goes undiagnosed when only fasting plasm... 17672859 - Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, p... 22519949 - Antidiabetic and antihypertensive effect of a polyphenol rich-fraction of thymeleae hir... 8096769 - Glutamine and glutamate in ascitic fluid of dogs. 9892779 - Human salivary sugar clearance after sugar rinses and intake of foodstuffs. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-03 |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: 89 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-10 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
|
Languages: eng Pagination: 250-5 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Endocrinology and Metabolism, The Armed Forces Capital Hospital, Gyeonggi, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Asian Continental Ancestry Group Female Glucose Intolerance / blood* Glucose Tolerance Test Humans Insulin / blood*, secretion Insulin Resistance / physiology* Male Middle Aged Prediabetic State / blood*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Circulating glycolaldehyde induces oxidative damage in the kidney of rats.
Next Document: Can phylogenetics identify C(4) origins and reversals?