Document Detail


Characteristics of individuals who excrete versus retain sodium under stress.
MedLine Citation:
PMID:  7562679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the role of stress on renal sodium excretion, we studied 27 normotensive and 21 hypertensive subjects. All subjects were placed on a standardized sodium diet. After water loading (2290 ml in 3 1/2 hr) they completed a 30 min baseline and a 30 min stress period (competitive videogame). Sixty-nine percent of the subjects increased ("excreters") and 31% decreased ("retainers") their sodium excretion under stress. In addition to increased potassium excretion (p < 0.006), excreters also manifested less of a stress associated increase in systolic (p = 0.055) and diastolic (p = 0.040) blood pressure and showed greater expression of anger (p < 0.02) than retainers. The same subjects were also studied to determin the effects of angiotensin converting enzyme inhibition (captopril 25 mg b.i.d.) on sodium excretion. On captopril, excreters now showed a retention of sodium (p < 0.001) and potassium (p < 0.01) under stress and no longer differed significantly in blood pressure reactivity. The results suggest that there are two different stress-related patterns of renal sodium excretion, that these patterns are related to blood pressure responses to stress, and may be related to anger expression. In addition, sodium excretion patterns under stress may be altered with certain type of antihypertensive medications.
Authors:
J D Rollnik; P J Mills; J E Dimsdale
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of psychosomatic research     Volume:  39     ISSN:  0022-3999     ISO Abbreviation:  J Psychosom Res     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-11-21     Completed Date:  1995-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376333     Medline TA:  J Psychosom Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  499-505     Citation Subset:  IM    
Affiliation:
Department of Medical Psychology, Ruhr-University of Bochum, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arousal / drug effects,  physiology
Blood Pressure / drug effects,  physiology
Captopril / therapeutic use
Cross-Over Studies
Double-Blind Method
Humans
Hypertension / drug therapy,  psychology,  urine*
Male
Middle Aged
Potassium / urine
Psychophysiologic Disorders / drug therapy,  psychology,  urine*
Sodium / urine*
Stress, Psychological / complications*
Water-Electrolyte Balance / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
HL-36005/HL/NHLBI NIH HHS; HL-40102/HL/NHLBI NIH HHS; RR-00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
62571-86-2/Captopril; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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