Document Detail

Characteristics of early-onset neonatal sepsis caused by Escherichia coli.
MedLine Citation:
PMID:  22482964     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was conducted to document the perinatal risk factors associated with early-onset neonatal Escherichia coli sepsis and adverse neonatal outcomes.
MATERIALS AND METHODS: A case-control study of early-onset E coli sepsis compared with that of non-E coli sepsis was conducted by a retrospective data review of all infants with a diagnosis of sepsis during the first 7 days of life from the pediatric unit of Mackay Memorial Hospital from January 2004 to October 2008. After adjustment for gestational age, each patient with E coli early-onset sepsis was further compared with two gestational age-matched uninfected controls.
RESULTS: Compared with infants with non-E coli sepsis (n = 27), infants with E coli sepsis (n = 19) were more likely to have preterm birth, especially at less than 30 weeks of gestation (47% vs. 4%, p < 0.01), very low birth weights (<1500 g; 47% vs. 4%, p < 0.01), intrapartum fever (26% vs. 4%, p = 0.036), preterm premature rupture of membranes (PPROM; 74% vs. 11%, p < 0.01), prolonged rupture of membranes (>24 hours; 47% vs. 0%, p < 0.01), antibiotic use (63% vs. 15%, p < 0.01), and sepsis onset on the first day of life (63% vs. 15%, p < 0.01). After adjusting for gestational age, intrapartum fever (26% vs. 5%, p = 0.035) and PPROM (74% vs. 39%, p = 0.015) were more common in infants with E coli sepsis. Fifteen of the 19 E coli isolates (79%) were ampicillin-resistant, and three (16%) were gentamicin-resistant. Antepartum and intrapartum antibiotic exposure was associated with ampicillin-resistant E coli sepsis (100% vs. 43%, p < 0.01).
CONCLUSION: Early-onset E coli sepsis is more common in premature and very low birth weight infants and is more likely associated with intrapartum fever, PPROM, and sepsis onset on the first day of life than non-E coli sepsis. Broad-spectrum, multiple antibiotics or longer duration of antibiotic exposure may be associated with antibiotic-resistant pathogen infection.
Chin-Han Tsai; Yi-Yung Chen; Kuo-Gon Wang; Chen-Yu Chen; Chie-Pein Chen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Taiwanese journal of obstetrics & gynecology     Volume:  51     ISSN:  1875-6263     ISO Abbreviation:  Taiwan J Obstet Gynecol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-08-27     Revised Date:  2013-05-10    
Medline Journal Info:
Nlm Unique ID:  101213819     Medline TA:  Taiwan J Obstet Gynecol     Country:  China    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Division of High Risk Pregnancy, Mackay Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Birth Weight*
Case-Control Studies
Escherichia coli*
Escherichia coli Infections / complications*,  drug therapy,  microbiology
Fetal Membranes, Premature Rupture / microbiology
Fever / microbiology
Gestational Age
Gram-Negative Bacterial Infections / complications,  microbiology
Infant, Newborn
Penicillin Resistance
Premature Birth / microbiology
Retrospective Studies
Risk Factors
Sepsis / drug therapy,  microbiology*
Streptococcal Infections / complications*,  microbiology
Streptococcus agalactiae
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
Taiwan J Obstet Gynecol. 2013 Mar;52(1):1-2   [PMID:  23548210 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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