Document Detail


Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in a large-scale Chinese population.
MedLine Citation:
PMID:  19781047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyse the phenotypic spectrum of polycystic ovary syndrome (PCOS) and determine the association between metabolic, hormonal and new ultrasonographic criteria. DESIGN: Clinical cross-sectional study. SETTING: University teaching hospital. POPULATION: A total of 804 Chinese women, among whom 719 cases were diagnosed as PCOS based on the 2003 Rotterdam criteria. Eighty-five women with regular menstrual cycles and without hyperandrogenism were recruited as controls. METHODS: PCOS patients were divided into four subgroups: (i) oligo- and/or anovulation (O), hyperandrogenism (H), and polycystic ovary morphology (P); (ii) O + H; (iii) H + P; and (iv) O + P. MAIN OUTCOME MEASUREMENTS: Clinical history, ultrasonographic (ovarian follicle number and volume), hormonal and metabolic parameters. RESULTS: The composition of the two new phenotypes created by the European Society for Human Reproduction and Embryology/The American Society for Reproductive Medicine (ESHRE/ASRM) 2003 was 65.6% (O + P and H + P). BMI and F-G scores were highest in the O + H + P group and lowest in O + P and controls. Serum testosterone concentrations and insulin resistance were highest in cases with O + H + P and O + H, intermediate in cases with H + P, and lowest in cases with O + P and controls. The prevalence of metabolic syndrome in the five groups was 28.5% (O + H + P), 25.5% (O + H), 8.3% (H + P), 7.2% (O + P) and 3.5% (controls), respectively. CONCLUSIONS: Nonclassic phenotypes for PCOS (O + P, H + P and O + H + P) were more frequent than the classic phenotype (O + H). The nonhyperandrogenic PCOS phenotype (O + P), one of the new phenotypes created by the Rotterdam criteria, may represent a form of PCOS associated with milder metabolic profile compared with the other phenotypes.
Authors:
H Y Zhang; F F Zhu; J Xiong; X B Shi; S X Fu
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Publication Detail:
Type:  Journal Article     Date:  2009-09-14
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  116     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1633-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Second Xiangya Hospital of Central South University, Hunan, China. zhanghongyuan830@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anovulation / etiology
Cross-Sectional Studies
Female
Humans
Insulin Resistance / physiology
Lipids / blood
Metabolic Syndrome X / etiology
Ovarian Follicle / pathology,  ultrasonography
Phenotype
Polycystic Ovary Syndrome / blood,  complications,  diagnosis*,  pathology
Testosterone / blood
Young Adult
Chemical
Reg. No./Substance:
0/Lipids; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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