Document Detail


Characteristics and correlates of cognitive functioning following bone marrow transplantation.
MedLine Citation:
PMID:  16086044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients who undergo bone marrow transplantation (BMT) often report cognitive problems following treatment. This study used cognitive tests and a self-report measure of subjective cognitive complaints to determine (1) the rate of objective cognitive impairment in a sample of 65 BMT patients, and (2) the correspondence of patients' cognitive complaints to their actual cognitive performance. At 6 months following BMT, patients were assessed in seven cognitive domains--attention, verbal learning, verbal memory, visual memory, simple executive function, complex executive function, and psychomotor speed. Cognitive complaints were likewise assessed. In all, 51% had at least mild impairment (-1 standard deviation (s.d.) below published norms) in one or more cognitive domains, with 28% demonstrating moderate-to-severe impairment (-2 s.d.). Older patients and patients with lower IQ were more likely to score in the impaired range on objective cognitive tests, with males and the less educated showing trends toward scores in the impaired range. Younger patients made significantly more cognitive complaints. Total cognitive complaints were unrelated to average cognitive performance, and complaints in specific cognitive domains were largely unrelated to objective performance on corresponding domains. Findings suggest that patients who complain about their cognitive performance following BMT differ from those who experience actual deficits.
Authors:
M Booth-Jones; P B Jacobsen; S Ransom; E Soety
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  36     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-11-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  IM    
Affiliation:
University of South Florida, and H Lee Moffitt Cancer Center, Psychosocial and Palliative Care, Tampa, FL 33612-9497, USA. jonesm@moffitt.usf.edu
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow Transplantation / psychology*
Cognition*
Cognition Disorders / epidemiology*,  etiology
Female
Humans
Intelligence Tests
Learning
Male
Memory
Neoplasms / surgery*
Postoperative Complications / psychology*
Reproducibility of Results
Speech
Transplantation, Autologous / psychology
Vision, Ocular

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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