| Characteristics of coronary microvascular lesions in autopsied elderly with hypertensive left ventricular hypertrophy. | |
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MedLine Citation:
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PMID: 12133530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To observe the characteristics of coronary microvascular lesions (CML) in the autopsied elderly cases with hypertensive left ventricular hypertrophy (LVH) and the difference of CML among the groups of essential hypertension (EHT), coronary heart disease (CHD) and diabetes (NIDDM) also with LVH. METHODS: A retrospective study was performed in 206 cases > or = 60 years old of EHT, CHD and NIDDM with LVH and 30 normal cases as control, out of 3195 consecutive autopsied cases from 1954 to 1996 in our hospital. Arterioles with diameters of 10 - 60 microm and capillaries in the muscular layer were shown by the methods of HE, Elastic fiber + VG staining and immunohistochemistry of CD31. Quantitative measurements on the arteriole density (AD), the ratio of arteriolar wall and cavity (RWC), capillary density (CD) and the area of endothelial cell (AEC) were performed with light microscope observation and image analysis by computer. According to the thickness of the left ventricle free wall, the severity of LVH was divided into four degrees from 0 to III. LVH of degree 0-III was observed in EHT group, while only LVH of degree I was found in CHD, EHT + CHD, and NIDDM groups. SAS system was used for statistical analysis. RESULTS: AD and RWC increased while CD and AEC decreased significantly with the progression of LVH in EHT groups (P < 0.05 - 0.01). There was a similar but more severe change in the (HT + CHD) group (P < 0.01); the AD increased (P < 0.05) while all other measurements did not show obvious changes in the CHD group. The AD increased, CD and AEC decreased (all P < 0.05), but RWC did not change very much in the NIDDM group. CONCLUSION: CML in the EHT group was characterized by an increased AD and RWC, decreased CD and AEC, among which the increased RWC was the typical change in EHT groups compared with the groups of CHD and NIDDM. Damaged CML may be one of the main factors for decreased coronary flow reserve and myocardial ischemia in cases of EHT with LVH. |
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Authors:
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Xiaoying Li; Rui Li; Wen Yu; Huaiyin Shi; Lixin Wei |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 115 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-07-22 Completed Date: 2002-08-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 658-63 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autopsy Coronary Circulation Coronary Disease / complications, pathology, physiopathology Coronary Vessels / pathology*, physiopathology Diabetes Mellitus, Type 2 / complications, pathology, physiopathology Female Humans Hypertension / complications, pathology*, physiopathology Hypertrophy, Left Ventricular / complications, pathology*, physiopathology Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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