Document Detail


Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France.
MedLine Citation:
PMID:  21067327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 657 sputum samples from 201 cystic fibrosis adult patients were collected during a 24-month period (2005-2006). We retrospectively analyzed the fungal colonization of the respiratory tract of these individuals by linking medical records and microbiological data. Filamentous fungi were isolated from specimens of 65.6% of the patients, with Aspergillus fumigatus being the predominant species recovered as it was found in specimens of 56.7% of the patients. We observed no difference for gender, pancreatic status and cirrhosis in patients with or without A. fumigatus colonization. We found a higher percentage of recovery of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and nontuberculous mycobacteria in patients with A. fumigatus colonization. During the follow-up period of the study, 8.9% of the patients were diagnosed with allergic bronchopulmonary aspergillosis (ABPA). By a multivariate analysis we demonstrated that Scedosporium apiospermum was significantly associated with ABPA (Odds ratio = 13 [2-80]) as opposed to A. fumigatus (Odds ratio = 1.58 [0.49-5.05]).
Authors:
André Paugam; Marie-Thérèse Baixench; Nadine Demazes-Dufeu; Pierre-Régis Burgel; Elise Sauter; Reem Kanaan; Daniel Dusser; Jean Dupouy-Camet; Dominique Hubert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical mycology     Volume:  48 Suppl 1     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2011-03-11     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S32-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aspergillosis, Allergic Bronchopulmonary / epidemiology,  microbiology
Aspergillus fumigatus / classification,  isolation & purification
Cystic Fibrosis / complications*,  epidemiology,  microbiology
Female
France / epidemiology
Fungi / isolation & purification*
Humans
Lung Diseases, Fungal / epidemiology*,  microbiology,  physiopathology*
Male
Middle Aged
Multivariate Analysis
Scedosporium / classification,  isolation & purification
Sputum / microbiology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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