Document Detail


Characteristics of chronic hepatitis B patients who underwent liver biopsies.
MedLine Citation:
PMID:  20726947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant liver disease has been reported in chronic hepatitis B patients with normal alanine aminotransferase (ALT) but most studies performed biopsies on selected patients only. The aims of this study were to determine the rate of liver biopsy, characteristics of patients who underwent a biopsy and factors associated with significant liver disease in a cohort of such patients. Records of patients with chronic hepatitis B during a 10-year period were reviewed. Significant liver disease was defined as Knodell HAI ≥ 7 and/or Ishak fibrosis ≥ 3. Of 743 patients, 55.7% were Asian, 56.4% were men, and the mean age was 43.1 years. One hundred and ninety-three (26%) had undergone a biopsy. Biopsied patients were more likely to be men, HBeAg positive, and had lower platelet and higher alkaline phosphatase, bilirubin, ALT and hepatitis B virus (HBV) DNA. Significant liver disease was observed in 20% of patients who had normal ALT at presentation, 14% of those with normal ALT at the time of biopsy and in none of the patients with persistently normal ALT. Patients with normal ALT who were biopsied had higher HBV DNA and higher ALT than those not biopsied. Multivariate analysis showed that low albumin at the time of biopsy and HBV DNA >5 log(10)  copies/mL were predictors of significant liver disease. Significant liver disease is rare in patients with chronic HBV and persistently normal ALT and liver histology of chronic HBV infected patients with normal ALT cannot be generalized to other patients with normal ALT that were not biopsied.
Authors:
W Chotiyaputta; B Degertekin; B J McKenna; N Samala; R J Fontana; A S F Lok
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-17
Journal Detail:
Title:  Journal of viral hepatitis     Volume:  18     ISSN:  1365-2893     ISO Abbreviation:  J. Viral Hepat.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-13     Completed Date:  2012-02-15     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9435672     Medline TA:  J Viral Hepat     Country:  England    
Other Details:
Languages:  eng     Pagination:  792-803     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alanine Transaminase / blood*
DNA, Viral / blood
Female
Health Records, Personal
Hepatitis B virus / isolation & purification
Hepatitis B, Chronic* / immunology,  pathology,  virology
Humans
Liver / pathology,  virology
Liver Cirrhosis / pathology
Male
Middle Aged
Serum Albumin
Grant Support
ID/Acronym/Agency:
UL1 RR024986/RR/NCRR NIH HHS; UL1 RR024986-04/RR/NCRR NIH HHS; UL1RR024986/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Serum Albumin; EC 2.6.1.2/Alanine Transaminase
Comments/Corrections

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