| Characteristics of cefdinir uptake by rabbit small intestinal brush-border membrane vesicles. | |
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MedLine Citation:
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PMID: 9178187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aminocephalosporins with peptide-like structures have been shown to be absorbed by the intestinal peptide carrier. We investigated the transport mechanism of cefdinir, an oral monocarboxylic acid cephalosporin, using rabbit small intestinal brush-border membrane vesicles. Transport of cefdinir showed a slow and almost linear uptake rate for concentrations up to 30 mM with and without and inward H+ gradient. No overshoot phenomenon was observed in the presence of an inward H+ gradient. The uptake rate increased only slightly with decreasing extravesicular pH, and a protonophore had little effect on the uptake. Aminocephalosporins such as cephalexin only slightly inhibited cefdinir uptake even in the presence of an inward H+ gradient, and vice-versa. Monocarboxylic acids such as acetic acid and salicylic acid had little effect on cefdinir uptake. These findings suggest that in contrast with other oral cephalosporins cefdinir uptake through the brush-border membrane is slow and involves a mechanism similar to passive diffusion. |
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Authors:
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S Kitagawa; Y Sugaya; Y Kaseda; S Sato |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 49 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-09-02 Completed Date: 1997-09-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 516-9 Citation Subset: IM |
Affiliation:
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Niigata College of Pharmacy, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carboxylic Acids / pharmacology Cephalosporins / pharmacokinetics*, pharmacology Drug Interactions Hydrogen-Ion Concentration Intestinal Absorption* / drug effects Intestine, Small / metabolism*, ultrastructure* Kinetics Microvilli / metabolism Rabbits Temperature |
| Chemical | |
Reg. No./Substance:
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0/Carboxylic Acids; 0/Cephalosporins; 91832-40-5/cefdinir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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