Document Detail

Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group.
MedLine Citation:
PMID:  18853278     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In the present study we measured carotid plaque morphology and plaque area by Duplex Doppler ultrasonography (US), as well as angiographic extent of carotid artery stenosis referred for carotid arteriography (DSA) in patients with two or more atherosclerotic risk factors, to assess the relation between features of carotid artery disease (CAD) and presenting cerebrovascular symptoms directly in the elderly. METHODS: Some 74 symptomatic (transient ischaemic attack (TIA) 17, amaurosis fugax 34, transient stroke 4, established stroke 10, progressive stroke 9) and 52 asymptomatic patients were studied with US and DSA. All patients was of 60-85 years old. Carotid plaque morphology (echolucent, echogenic or complex) and plaque area were assessed with US, and luminal stenosis was measured with DSA. Spearman correlation analysis was performed to identify the association between characteristics of CAD and presenting symptoms. RESULTS: Symptomatic patients with echolucent and complex plaque were common than that with echogenic plaque (P < 0.05 and P < 0.01 respectively). With advanced plaque area and degree of carotid luminal stenosis, the incidence of general symptom had increased significantly, but percentage of patients with regular treatment had decreased gradually. Spearman correlation analysis confirmed that presenting symptoms was in direct correlation with Carotid Plaque Area (P < 0.05) and carotid luminal stenosis (P < 0.05), but was in negative correlation with regular treatment of cardiovascular risk (P < 0.01). Analysis showed that features of CAD did not distinguish between types of symptomatic patients. CONCLUSIONS: There was an association between features of CAD and the presence of symptoms but not their type in the elderly. Identifying high risk elderly patients of CAD and giving regular treatment earlier might stabilize the plaque, reduce the plaque area and the progression in luminal stenosis, then decline or prevent the incidence of presenting cerebrovascular symptoms.
Qingwei Chen; Ying Liu; Linlin Pei; Dazhi Ke; Guiqiong Li; Wei Deng; Wuwei Yao
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Publication Detail:
Type:  Journal Article     Date:  2008-10-14
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  25     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Department of Geriatrics Cardiology, The Second Affiliated Hospital of ChongQing University of Medical Science, ChongQing City 400010, China.
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MeSH Terms
Aged, 80 and over
Amaurosis Fugax / etiology*
Analysis of Variance
Angiography, Digital Subtraction
Carotid Stenosis / complications*,  radiography*,  ultrasonography*
Cerebral Angiography*
Ischemic Attack, Transient / etiology*
Middle Aged
Risk Factors
Stroke / etiology*
Ultrasonography, Doppler, Duplex*

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