Document Detail

Characteristics associated with rapid decline in forced expiratory volume.
MedLine Citation:
PMID:  8827157     Owner:  NLM     Status:  MEDLINE    
Cigarette smoking is known to accelerate decline of pulmonary function; however, the role of other factors is less clear. Characteristics of individuals who experienced rapid decline in forced expiratory volume in 1-sec (FEV1) were examined in 4451 Japanese-American men from the Honolulu Heart Program who were aged 45 to 68 years at baseline (1965-1968) and who produced three acceptable FEV1 measures over a 6-year period. Average annual rates of FEV1 decline were calculated by use of within-person regression and were categorized as rapid (> or = 60 ml/y), moderate (30 to 59 ml/y) or slow (< 30 ml/y). Lifestyle and biologic factors were compared by FEV1 decline categories after adjustment for age. A logistic regression model showed that continued smoking during follow-up, cigarette pack-years, wheezing, coronary heart disease, alcohol intake, and reduced subscapular skinfold were significantly associated with rapid FEV1 decline, after adjustment for age, height, cholesterol, an indicator of Japanese diet, and education. When analyses were restricted to continuous smokers, cigarette pack-years, wheezing, and reduced subscapular skinfold were found to be independent predictors. Among never smokers, lower educational attainment was a predictor of rapid FEV1 decline, and the association involving subscapular skinfold approached significance (P < 0.07). These characteristics may be useful in identifying subgroups of the population who are at increased risk of accelerated decline in pulmonary function and thus would be most likely to benefit from appropriate intervention.
C M Burchfiel; E B Marcus; D S Sharp; P L Enright; B L Rodriguez; K H Masaki; L J Hwang; J D Curb
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of epidemiology     Volume:  6     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-10-22     Completed Date:  1996-10-22     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-27     Citation Subset:  IM    
Honolulu Epidemiology Research Unit, National Heart, Lung, and Blood Institute, Honolulu, Hawaii, USA.
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MeSH Terms
Asian Americans*
Body Constitution
Body Mass Index
Diet / adverse effects
Educational Status
Forced Expiratory Volume*
Hawaii / epidemiology
Japan / ethnology
Linear Models
Logistic Models
Longitudinal Studies
Lung Diseases / epidemiology*,  etiology
Middle Aged
Odds Ratio
Respiratory Sounds / physiopathology
Risk Factors
Smoking / adverse effects,  epidemiology,  physiopathology*
Time Factors
Grant Support

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