Document Detail

Characteristics of arterial stiffness in very low birth weight premature infants.
MedLine Citation:
PMID:  16988197     Owner:  NLM     Status:  MEDLINE    
Premature birth is a factor of increased blood pressure in adulthood. Little is known about the physiologic characteristics of the arterial bed in neonates. The aim of this study was to characterize in vivo the arterial compliance in neonates and its maturation profile in very low birth weight (VLBW) premature infants. A group of stable, VLBW premature infants was compared with a control group of near term neonates. The abdominal aortic wall distensibility coefficient (DC) and whole-body arterial compliance (WBAC) were determined using specifically designed noninvasive methods, based on ultrasonic measurements in combination with synchronous, beat-to-beat recording of aortic pulse pressure (PP). On the fifth day of life, WBAC and the CD were lower in VLBW premature infants than in controls. Furthermore, WBAC and the DC remained unchanged in VLBW premature infants 7 wk after birth. In conclusion, VLBW premature infants are characterized as early as the fifth day of life by high arterial stiffness, which persists when they reach their theoretical term. It can be speculated that early alteration of arterial elastic properties may pave the way for long-term elevation of arterial pressure in VLBW premature infants.
Laurent Tauzin; Pascal Rossi; Bernard Giusano; Jean Gaudart; Alain Boussuges; Alain Fraisse; Umberto Simeoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-20
Journal Detail:
Title:  Pediatric research     Volume:  60     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-6     Citation Subset:  IM    
Division of Neonatology, Assitance Publique, Hôpitaux de Marseille and Faculté de Médecine, Université de la Méditerranée, 13000 Marseille, France.
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MeSH Terms
Arteries / pathology*
Blood Pressure / physiology
Gestational Age
Infant, Newborn
Infant, Very Low Birth Weight*
Vascular Resistance / physiology*

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