Document Detail

Characteristics of aortic wall extracellular matrix in patients with acute myocardial infarction: tissue microarray detection of collagen I, collagen III and elastin levels.
MedLine Citation:
PMID:  23049084     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Extracellular matrix (ECM) remodelling of the vessel wall is hypothesized to be an important step in atherosclerosis. Changes of the ECM are associated with the gradual progression of an atherosclerotic lesion from a lipid streak to complicated unstable plaque, leading to a complete vessel occlusion and eventually myocardial infarction (MI). Understanding of this process is critical in the treatment and prevention of ischaemic heart disease (IHD).
METHODS: We investigated the histopathological characteristics of aortic wall ECM in IHD patients. Collagen I, collagen III and elastin were assessed immunohistochemically in patients with acute MI and those with stable angina, using aortic punch tissues obtained from coronary artery bypass graft surgery. Fluorescence tissue images were analysed using the tissue microarray technique.
RESULTS: The results showed that collagen III expression was found to be significantly lower in the acute MI group (P < 0.001). As a result of this change, the patients with MI also revealed a significant reduction in the collagen III/collagen I ratio. The elastin/collagen III ratio was significantly higher in the MI group (P < 0.001).
CONCLUSIONS: Our study provided evidence of a decrease in collagen III content in patients with MI, which could possibly explain the mechanism of plaque vulnerability and weakening of the plaque cap. A reduction in collagen III content, particularly away from the atherosclerotic lesions, might be explained by the systemic vascular changes in patients with MI, and inflammation and immune responses could be potential causes of these systemic transformations. The biochemical mechanisms and factors regulating collagen III production might be potential markers to predict possible cardiovascular events.
Chee Hoe Kong; Xiao Yun Lin; Chin Cheng Woo; Hung Chew Wong; Chuen Neng Lee; A Mark Richards; Vitaly A Sorokin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-09
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  16     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-05-31     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-5     Citation Subset:  IM    
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MeSH Terms
Angina, Stable / metabolism*,  pathology,  surgery
Aorta / chemistry*,  pathology
Biological Markers / analysis
Case-Control Studies
Collagen Type I / analysis*
Collagen Type III / analysis*
Coronary Artery Bypass
Elastin / analysis*
Microscopy, Fluorescence
Middle Aged
Myocardial Infarction / metabolism*,  pathology,  surgery
Tissue Array Analysis*
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Collagen Type III; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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