Document Detail

Characteristics of aldosterone antisera related to the duration of immunization.
MedLine Citation:
PMID:  1002114     Owner:  NLM     Status:  MEDLINE    
Three antisera specific to aldosterone and elicited with different aldosterone protein conjugates (aldosterone-3-oxine rabbit serum albumin and aldosterone-3-oxime bovine gamma-globulin) were studied by radioimmunological methods at various times subsequent to first-immunization. A considerable variability of the parameters important in radioimmunoassay was observed over the whole experimental period. Titer, sensitivity and specificity of two antisera tended to increase as long as the animals were boosted. In the third they did not change in a uniform way.
U Schmied; W Siegenthaler; J Nussberger; R Beckerhoff; W Vetter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  7     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1976  
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
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MeSH Terms
Aldosterone / immunology*
Cross Reactions
Dose-Response Relationship, Drug
Immune Sera*
Rabbits / immunology
Time Factors
Reg. No./Substance:
0/Antibodies; 0/Immune Sera; 0/Oximes; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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