Document Detail


Characteristics of adult patients with atrial septal defects presenting with paradoxical embolism.
MedLine Citation:
PMID:  19670302     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: The association between patent foramen ovale (PFO), atrial septal aneurysm, and cryptogenic stroke due to paradoxical embolism has been established. The correlation between atrial septal defect (ASD) in adults and paradoxical embolism is less well defined. METHODS: We examined our single center experience with 329 adult patients undergoing percutaneous device closure of interatrial communication defects to identify clinical and morphologic differences among adult patients with ASDs who presented with or without paradoxical embolism. Comparison was made with patients with PFO. RESULTS: Although a significant left-to-right shunt was the predominant indication for ASD closure, 20 patients (14%) presented with a paradoxical embolism. These patients tended to be younger and had smaller defects (both by size and shunt ratio) than ASD patients without paradoxical embolism, and were more likely to be female than PFO patients. CONCLUSIONS: The incidence of adult patients with ASD who presented with paradoxical embolism is higher than expected and suggests that this diagnosis should be considered in patients with cryptogenic stroke.
Authors:
Amr Bannan; Rhuna Shen; Frank E Silvestry; Howard C Herrmann
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  74     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1066-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
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Comment In:
Catheter Cardiovasc Interv. 2009 Dec 1;74(7):1070-1   [PMID:  19950331 ]

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