Document Detail

Characteristics of adrenocortical function, gastrin release and gastric secretion in duodenal ulcer etiology.
MedLine Citation:
PMID:  381739     Owner:  NLM     Status:  MEDLINE    
Measurements of serum cortisol and gastrin along with gastric acid-pepsin secretion in the resting state were carried out in gastric and duodenal ulcer patients. Increased basal corticosteroid concentrations were observed in patients with duodenal ulcer and gastric ulcer. Higher concentrations of the hormone were observed in the former group (P less than 0.05 for the latter). Fasting gastrin levels were significantly higher in gastric ulcer patients where gastric secretion is low than those in duodenal ulcer patients (P less than 0.001). These results suggest that the effect of adrenal cortical hormone on lowering the threshold of oxyntic gland cell reactivity against gastrin is an important factor in duodenal ulcer etiology. Extra-antral control mechanism(s) of gastric acid-pepsin secretion should not be overlooked.
Y Nagamachi; A Taniguchi; N Ogata; T Nakamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of surgery     Volume:  9     ISSN:  0047-1909     ISO Abbreviation:  Jpn J Surg     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302176     Medline TA:  Jpn J Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  196-202     Citation Subset:  IM    
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MeSH Terms
Adrenal Cortex Hormones / secretion*
Duodenal Ulcer / etiology,  physiopathology*
Gastric Juice / secretion*
Gastrins / blood,  secretion*
Hydrocortisone / secretion
Middle Aged
Pepsin A / secretion
Stomach Ulcer / physiopathology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Gastrins; 50-23-7/Hydrocortisone; EC A

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