| Characteristics of the active lymph pump in bovine prenodal mesenteric lymphatics. | |
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MedLine Citation:
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PMID: 17935475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The functional characteristics of the bovine mesenteric postnodal lymphatics are well-described. However there are no reports of pumping characteristics of the bovine mesenteric prenodal lymphatics. We propose that the prenodal lymphatics have adapted to the local conditions of lymph flow and are functioning differently than the postnodal vessels. METHODS AND RESULTS: To evaluate pumping in bovine prenodal mesenteric lymphatics, we observed their contractility in response to the changes in transmural pressure and imposed flow. Lymphatics (diameter approximately 460 microm) were isolated, cannulated, and pressurized. Lymphatic diameters were traced from video records; the lymphatic tone index, contraction amplitude and frequency, lymphatic pump indices were calculated. Increasing transmural pressure from 3 to 6 cm H2O produced a strong inotropic response, but did not induce a significant chronotropic response. Pumping reached its maximum at transmural pressures 6-9 cm H2O and was not significantly depressed up to 15 cm H2O, whereas pumping in postnodal lymphatics is typically depressed at transmural pressures higher than 10 cm H2O. Bovine prenodal mesenteric lymphatics also demonstrated very low sensitivity to the increases in imposed flow. CONCLUSIONS: We concluded that the functional heterogeneity exists on the intraregional levels in lymphatic nets. |
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Authors:
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Anatoliy A Gashev; Wei Wang; Glen A Laine; Randolph H Stewart; David C Zawieja |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lymphatic research and biology Volume: 5 ISSN: 1539-6851 ISO Abbreviation: Lymphat Res Biol Publication Date: 2007 |
Date Detail:
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Created Date: 2007-10-15 Completed Date: 2007-12-27 Revised Date: 2011-02-21 |
Medline Journal Info:
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Nlm Unique ID: 101163587 Medline TA: Lymphat Res Biol Country: United States |
Other Details:
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Languages: eng Pagination: 71-9 Citation Subset: IM |
Affiliation:
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Department of Systems Biology and Translational Medicine, College of Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A&M Health Science Center, 336 Reynolds Medical Bldg, College Station, TX 77843-1114, USA. gashev@tamu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Lymph / physiology* Lymph Nodes / physiology Lymphatic System / physiology* Lymphatic Vessels / physiology* Mesentery / physiology* Pressure |
| Grant Support | |
ID/Acronym/Agency:
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HL-07688/HL/NHLBI NIH HHS; R01 HL075199-04/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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