Document Detail

Characteristics of visual field progression in medically treated normal-tension glaucoma patients with unstable ocular perfusion pressure.
MedLine Citation:
PMID:  20861474     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the characteristics of visual field (VF) progression in medically treated normal-tension glaucoma (NTG) patients (Koreans) with unstable ocular perfusion pressure (OPP).
METHODS: One hundred one eyes of 101 NTG patients followed up for more than 4 years (mean follow-up, 6.2 years ± 12.1 months) were included. Modified Anderson criteria (MC) and linear regression analysis (LA) of VF mean deviation (MD) within the central 10° and 10° to 24° area were assessed for determining VF progression in groups with lowest (LMF) and highest (HMF) 24-hour mean OPP [MOPP = 2/3;(mean arterial pressure - IOP)] fluctuation. Kaplan-Meier analyses were used to compare the elapsed time of confirmed VF progression in the two groups. Hazard ratios (HRs) for the association between clinical risk factors including 24-hour MOPP and central VF progression were obtained by using Cox proportional hazards models.
RESULTS: Three of 33 eyes in the LMF progressed, whereas 12 of 34 eyes in the HMF progressed within the central 10° according to the MC; the between-group difference was significant (P = 0.010). By LA within the central 10°, two eyes from the LMF and nine from the HMF groups showed progression (P = 0.025). The HMF showed a greater cumulative probability of central VF progression than the LMF, by both LA and MC (Kaplan-Meier analysis, P = 0.003, 0.015, log-rank test). In multivariate analysis, only 24-hour MOPP fluctuation was significantly associated with central VF progression (P = 0.014).
CONCLUSIONS: The 24-hour MOPP fluctuation was the most consistent prognostic factor among various IOP, blood pressure, and clinical factors for central VF glaucomatous progression in our series of NTG eyes.
Kyung Rim Sung; Jung Woo Cho; Suhwan Lee; Sung-Cheol Yun; Jaewan Choi; Jung Hwa Na; Youngrok Lee; Michael Scott Kook
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Publication Detail:
Type:  Journal Article     Date:  2011-02-09
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-10     Completed Date:  2011-04-01     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-43     Citation Subset:  IM    
Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Songpa-gu, Seoul, Korea.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology
Disease Progression
Drug Combinations
Follow-Up Studies
Intraocular Pressure / physiology*
Low Tension Glaucoma / diagnosis,  drug therapy*,  physiopathology*
Middle Aged
Proportional Hazards Models
Retrospective Studies
Tonometry, Ocular
Vision Disorders / physiopathology*
Visual Fields / physiology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Drug Combinations

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