| Characteristics of primary papillary thyroid carcinoma with false-negative findings on initial (18)F-FDG PET/CT. | |
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MedLine Citation:
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PMID: 21140231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We often observe that uptake of tracer is not detected in the primary cancer focus in patients with histologically proven papillary thyroid carcinoma (PTC) on preoperative (18)F-fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET/CT). Therefore, we analyzed the clinical and pathologic variables affecting false-negative findings in primary tumors on preoperative (18)F-FDG PET/CT. METHODS: We retrospectively reviewed the medical records of 115 consecutive patients who underwent (18)F-FDG PET/CT for initial evaluation and were diagnosed with PTC by postoperative permanent biopsy. The clinical and pathologic characteristics that influence the (18)F-FDG PET/CT findings in these patients were analyzed with respect to the following variables: age, gender, tumor size, multifocality of the primary tumor, perithyroidal invasion, lymphovascular or capsular invasion, and central lymph node metastasis-based final pathology. RESULTS: Twenty-six (22.6%) patients had false-negative (18)F-FDG PET/CT findings. In patients with negative (18)F-FDG PET/CT findings, tumor size, and perithyroidal and lymphovascular invasion were significantly less than in patients with positive (18)F-FDG PET/CT findings. Tumors >1 cm in size were correlated with (18)F-FDG PET/CT positivity. On multivariate analysis, perithyroidal invasion (P = 0.026, odds ratio = 7.714) and lymphovascular invasion (P = 0.036, odds ratio = 3.500) were independent factors for (18)F-FDG PET/CT positivity. However, there were no significant differences between (18)F-FDG PET/CT positivity and age, gender, capsular invasion, and central lymph node metastasis based on final pathology. CONCLUSIONS: Tumor size and perithyroidal and lymphovascular invasion of papillary carcinoma can influence (18)F-FDG PET/CT findings. Absence of perithyroidal and lymphovascular invasion were independent variables for false-negative findings on initial (18)F-FDG PET/CT in patients with PTC. |
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Authors:
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Jin Woong Choi; Young Hoon Yoon; Yeo Hoon Yoon; Seong Min Kim; Bon Seok Koo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-12-08 |
Journal Detail:
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Title: Annals of surgical oncology Volume: 18 ISSN: 1534-4681 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-08-30 Revised Date: 2012-01-11 |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1306-11 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Papillary / diagnosis*, surgery False Negative Reactions Female Fluorodeoxyglucose F18 / diagnostic use* Humans Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Positron-Emission Tomography* Prognosis Radiopharmaceuticals / diagnostic use* Retrospective Studies Thyroid Neoplasms / diagnosis*, surgery Tomography, X-Ray Computed* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
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Ann Surg Oncol. 2011 Dec;18 Suppl 3:S304-5
[PMID:
21537860
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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