Document Detail


Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying.
MedLine Citation:
PMID:  21397732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Chronic nausea and vomiting with normal gastric emptying is a poorly understood syndrome; we analyzed its characteristics.
METHODS: We collected and analyzed data from 425 patients with chronic nausea and vomiting, enrolled at 6 centers by the Gastroparesis Clinical Research Consortium in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Registry.
RESULTS: Among the patients, 319 (75%) had delayed emptying, defined by the results of a standardized, low-fat meal, and 106 had normal gastric emptying. Patients with or without delayed emptying did not differ in age, sex, or race, although those with normal gastric emptying were less likely to be diabetic. Symptom severity indexes were similar between groups for nausea, retching, vomiting, stomach fullness, inability to complete a meal, feeling excessively full after meals, loss of appetite, bloating, and visibly larger stomach. There were no differences in health care utilization, quality of life indexes, depression, or trait anxiety scores. However, state anxiety scores were slightly higher among patients with delayed gastric emptying. Total gastroparesis cardinal symptom index scores were not correlated with gastric retention after 2 or 4 hours in either group. Patients with the syndrome were not adequately captured by the stand-alone criteria for the Rome III diagnoses of chronic idiopathic nausea and functional vomiting. With rare exceptions, the diagnosis remained stable after a 48-week follow-up period.
CONCLUSIONS: Patients with nausea and vomiting with normal gastric emptying represent a significant medical problem and are, for the most part, indistinguishable from those with gastroparesis. This syndrome is not categorized in the medical literature--it might be a separate clinical entity.
Authors:
Pankaj J Pasricha; Ryan Colvin; Katherine Yates; William L Hasler; Thomas L Abell; Aynur Unalp-Arida; Linda Nguyen; Gianrico Farrugia; Kenneth L Koch; Henry P Parkman; William J Snape; Linda Lee; James Tonascia; Frank Hamilton
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-11
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  9     ISSN:  1542-7714     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-24     Completed Date:  2011-10-13     Revised Date:  2014-07-18    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  567-76.e1-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Chronic Disease
Diagnosis, Differential
Female
Gastric Emptying / physiology*
Gastroparesis / diagnosis*
Humans
Male
Middle Aged
Nausea / diagnosis*,  epidemiology*
Vomiting / diagnosis*,  epidemiology*
Grant Support
ID/Acronym/Agency:
U01 DK073974-05/DK/NIDDK NIH HHS; U01 DK073975-05/DK/NIDDK NIH HHS; U01 DK073983-05/DK/NIDDK NIH HHS; U01 DK073985/DK/NIDDK NIH HHS; U01 DK073985-05/DK/NIDDK NIH HHS; U01 DK074007/DK/NIDDK NIH HHS; U01 DK074007-05/DK/NIDDK NIH HHS; U01 DK074008/DK/NIDDK NIH HHS; U01 DK074008-05/DK/NIDDK NIH HHS; U01DK073974/DK/NIDDK NIH HHS; U01DK073975/DK/NIDDK NIH HHS; U01DK073983/DK/NIDDK NIH HHS; U01DK073985/DK/NIDDK NIH HHS; U01DK074007/DK/NIDDK NIH HHS; U01DK074008/DK/NIDDK NIH HHS
Comments/Corrections
Comment In:
Clin Gastroenterol Hepatol. 2011 Jul;9(7):534-5   [PMID:  21440667 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A sustained virologic response reduces risk of all-cause mortality in patients with hepatitis C.
Next Document:  Direct Peroral Cholangioscopy Using a Novel Anchoring Balloon.