Document Detail


Characteristics of MR infarcts associated with dementia and cognitive function in the elderly.
MedLine Citation:
PMID:  22179433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Little information exists on the simultaneous effects of magnetic resonance (MR) infarct characteristics, that may increase the likelihood of dementia or lower cognitive function in community populations.
METHODS: Participants were 580 community-dwelling individuals from the Chicago Health and Aging Project (CHAP) who underwent detailed clinical evaluation and MR imaging. The association of MR infarct characteristics (region, number, side, and size) with dementia, global cognition and cognition in five separate cognitive domains was examined using logistic and linear regression analyses controlling for age, sex, race, education and time elapsed between clinical evaluation and MRI.
RESULTS: A total of 156 persons had MR infarcts: 108 with 1 infarct and 48 with multiple. Poorer cognitive function and, in particular, slower perceptual speed, were associated with infarcts characterized as cortical, multiple, bilateral or large (all p < 0.05). Multiple infarcts in multiple regions were associated with poor performance in all cognitive domains except visuospatial ability (p < 0.05). Race did not modify any of these associations.
CONCLUSIONS: In this community sample, cortical and multiple infarcts in multiple regions were associated with dementia; cortical, multiple, large and bilateral infarcts were associated with lower cognition, particularly lower memory function and perceptual speed. These effects were not modified by race.
Authors:
Neelum T Aggarwal; Julie A Schneider; Robert S Wilson; Todd L Beck; Denis A Evans; Charles De Carli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-17
Journal Detail:
Title:  Neuroepidemiology     Volume:  38     ISSN:  1423-0208     ISO Abbreviation:  Neuroepidemiology     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-05-18     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Rush University Medical Center, Chicago, IL 60612, USA. Neelum_T_Aggarwal @ rush.edu
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Aged
Aged, 80 and over
Causality
Cerebral Infarction / diagnosis*,  epidemiology*
Chicago / epidemiology
Cognition Disorders / epidemiology*
Cohort Studies
Comorbidity
Dementia / epidemiology*
Female
Humans
Logistic Models
Longitudinal Studies
Magnetic Resonance Imaging*
Male
Odds Ratio
Sex Distribution
Grant Support
ID/Acronym/Agency:
AG11101/AG/NIA NIH HHS
Comments/Corrections

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