| Characteristics of MR infarcts associated with dementia and cognitive function in the elderly. | |
| | |
MedLine Citation:
|
PMID: 22179433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Little information exists on the simultaneous effects of magnetic resonance (MR) infarct characteristics, that may increase the likelihood of dementia or lower cognitive function in community populations. METHODS: Participants were 580 community-dwelling individuals from the Chicago Health and Aging Project (CHAP) who underwent detailed clinical evaluation and MR imaging. The association of MR infarct characteristics (region, number, side, and size) with dementia, global cognition and cognition in five separate cognitive domains was examined using logistic and linear regression analyses controlling for age, sex, race, education and time elapsed between clinical evaluation and MRI. RESULTS: A total of 156 persons had MR infarcts: 108 with 1 infarct and 48 with multiple. Poorer cognitive function and, in particular, slower perceptual speed, were associated with infarcts characterized as cortical, multiple, bilateral or large (all p < 0.05). Multiple infarcts in multiple regions were associated with poor performance in all cognitive domains except visuospatial ability (p < 0.05). Race did not modify any of these associations. CONCLUSIONS: In this community sample, cortical and multiple infarcts in multiple regions were associated with dementia; cortical, multiple, large and bilateral infarcts were associated with lower cognition, particularly lower memory function and perceptual speed. These effects were not modified by race. |
| | |
Authors:
|
Neelum T Aggarwal; Julie A Schneider; Robert S Wilson; Todd L Beck; Denis A Evans; Charles De Carli |
Related Documents
:
|
7391343 - Transthoracic electrical impedance during extracorporeal hemodialysis in acute respirat... 11739843 - Chronic dyspnea and hyperventilation in an awake patient with small subcortical infarcts. 21814193 - The use of beat-to-beat electrocardiogram analysis to distinguish qt/qtc interval chang... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-17 |
Journal Detail:
|
Title: Neuroepidemiology Volume: 38 ISSN: 1423-0208 ISO Abbreviation: Neuroepidemiology Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-01-24 Completed Date: 2012-05-18 Revised Date: 2013-02-20 |
Medline Journal Info:
|
Nlm Unique ID: 8218700 Medline TA: Neuroepidemiology Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 41-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Rush University Medical Center, Chicago, IL 60612, USA. Neelum_T_Aggarwal @ rush.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Distribution Aged Aged, 80 and over Causality Cerebral Infarction / diagnosis*, epidemiology* Chicago / epidemiology Cognition Disorders / epidemiology* Cohort Studies Comorbidity Dementia / epidemiology* Female Humans Logistic Models Longitudinal Studies Magnetic Resonance Imaging* Male Odds Ratio Sex Distribution |
| Grant Support | |
ID/Acronym/Agency:
|
AG11101/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Downregulation of Dicer, a component of the microRNA machinery, in bladder cancer.
Next Document: Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal...