Document Detail


Characteristics of Inflammatory Bowel Disease with an Onset before Eight Years of Age: A Multicenter Epidemiological Survey in Japan.
MedLine Citation:
PMID:  23216419     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Pediatric inflammatory bowel disease (IBD) has not been rare in Japan since the 1990s. The present study attempted to define the epidemiological and clinical characteristics of early-childhood IBD in Japan, in comparison with results from Western countries. METHODS: Among children diagnosed as having IBD between January 1998 and December 2008, those showing onset before 8 years of age were investigated retrospectively. A questionnaire survey was carried out at 45 facilities throughout Japan, and 80 cases were reported from 27 facilities. On the basis of the final diagnosis, 24 patients with Crohn's disease (CD) and 47 patients with ulcerative colitis (UC) were analyzed. RESULTS: Among the patients with CD, the age at onset was less than one year in 62.5%. On the basis of the Montreal classification, 87.5% of CD cases involved the colon and 63.8% of UC cases were pancolitis. Co-existing conditions such as congenital diseases (5 cases) and cerebral palsy (4 cases) were present before the onset of IBD. Growth failure was more severe (P <0.05) at diagnosis in CD patients than in UC patients. Familial occurrence within first-degree relatives was observed in 8 families among 45 patients with UC, compared with none among the CD patients (P <0.05). CONCLUSION: Our results suggest that, in Japan, the pathogenesis of IBD in infants and children may differ from that in Western countries, and that the characteristics of early childhood-onset IBD are distinct from those of school age-onset IBD.
Authors:
Shun-Ichi Maisawa; Mika Sasaki; Shinobu Ida; Keiichi Uchida; Seiichi Kagimoto; Toshiaki Shimizu; Atsushi Yoden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-6
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Pediatrics, Morioka Children's Hospital, Morioka, Japan.
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