Document Detail


Characteristics of Devic's disease (neuromyelitis optica) in Mexico.
MedLine Citation:
PMID:  18283393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To report clinical and epidemiological data of Devic's disease in Mexico. DESIGN: Retrospective study of hospital case records. SETTING: The medical records were those of the National Institute for Neurology and Neurosurgery (INNN), a tertiary care referral center in Mexico City. PATIENTS: There were 424 medical histories available for review among 561 discharges with diagnoses of multiple sclerosis (MS), neuromyelitis optica (NMO), or equivalents. 390 met the diagnostic criteria of MS and 34 the NMO criteria. MAIN OUTCOME MEASURES: We recorded clinical signs, visual acuities, and the Expanded Disability Status Scale (EDSS) at the initial diagnostic admission and during follow-up. All patients had examination of cerebrospinal fluid (CSF) at diagnosis; head and spine magnetic resonance imaging (MRI) were performed at diagnosis and at follow-up. RESULTS: All 34 patients were Mexican Mestizos, who comprise 79 % of the residents of Mexico City. There were 23 monophasic and 11 relapsing cases. Intervals between initial and defining events for the 8 ON and 12 myelitis onsets were 17 and 24 months (means) and 15 and 17 months (medians), respectively. Mean follow- up from onset was 70.2 months and 42.9 months from diagnostic examination. No patient showed improvement in EDSS scores. Visual loss was severe. CONCLUSION: A provisional prevalence rate of about 1 per 100,000 population for NMO in Mexican Mestizos might be offered. The disease seems more severe in our population than in other recent series.
Authors:
John Flores Rivera; John F Kurtzke; Vanessa J Alatriste Booth; Teresa Corona V
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Publication Detail:
Type:  Journal Article     Date:  2008-02-19
Journal Detail:
Title:  Journal of neurology     Volume:  255     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-08-20     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  710-5     Citation Subset:  IM    
Affiliation:
Dept. of Neurology, National Institute of Neurology and Neurosurgery, Insurgentes sur 3877, Mexico City, CP 14362, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Disease Progression
Female
Humans
Magnetic Resonance Imaging
Male
Mexico / epidemiology
Neuromyelitis Optica / diagnosis*,  epidemiology*,  physiopathology
Optic Nerve / pathology*,  physiopathology
Prevalence
Recurrence
Retrospective Studies
Severity of Illness Index
Spinal Cord / pathology*,  physiopathology
Vision, Low / etiology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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