| Characteristics and determinants of adiposity in pediatric cancer survivors. | |
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MedLine Citation:
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PMID: 20647396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adiposity and the diseases associated with it, including cardiovascular disease, are emerging long-term complications of pediatric cancer survivors. Direct evaluations of adiposity and comparisons to contemporary controls that can differentiate recent trends in obesity from cancer-related treatments and sequelae are limited. METHODS: We evaluated demographic, treatment, lifestyle, and endocrine factors at the time of dual-energy X-ray absorptiometry testing in 170 non-Hispanic white survivors and 71 sibling controls, and compared three measures of adiposity [body mass index (BMI), total body fat, and trunk fat]. For the survivors alone, we determined factors independently associated with BMI and body fat. RESULTS: Survivors were at 12 years since diagnosis; 58% had leukemia or lymphoma. BMI did not differ between groups. Among males, body fat was greater in survivors than in controls (25.8% versus 20.7%; P = 0.007), as was trunk fat (26.7% versus 21.3%; P = 0.008). Total or trunk fat did not differ among females. Cholesterol, triglycerides, low-density lipoprotein cholesterol, and television viewing hours were higher among male survivors than in controls. Independent factors associated with higher BMI and total and trunk fat included any cranial radiation and television viewing hours, whereas prior treatment with cyclophosphamide was associated with lower BMI and body fat measures. CONCLUSIONS: Compared with siblings, male survivors have greater body fat and metabolic risks. Cranial irradiation and television hours are important risk factors for adiposity in pediatric cancer survivors. IMPACT: Pediatric cancer survivors should be carefully monitored for cardiovascular risk factors and sedentary lifestyles. |
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Authors:
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Tracie L Miller; Stuart R Lipsitz; Gabriela Lopez-Mitnik; Andrea S Hinkle; Louis S Constine; M Jacob Adams; Carol French; Cynthia Proukou; Amy Rovitelli; Steven E Lipshultz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-20 |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 19 ISSN: 1538-7755 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 2013-22 Citation Subset: IM |
Copyright Information:
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(c)2010 AACR. |
Affiliation:
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Batchelor Children's Research Institute, Division of Pediatric Clinical Research, Department of Pediatrics (D820), Miller School of Medicine, University of Miami, Miami, FL 33101, USA. tracie.miller@miami.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue Adiposity* Adolescent Adult Body Mass Index Cardiovascular Diseases / etiology* Case-Control Studies Child European Continental Ancestry Group Female Humans Male Neoplasms / complications* Prospective Studies Risk Factors Sex Factors Siblings Survivors / statistics & numerical data* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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CA-127642/CA/NCI NIH HHS; CA-79060/CA/NCI NIH HHS; M01 RR00054/RR/NCRR NIH HHS; M01-RR00044/RR/NCRR NIH HHS; P01 DK-45734/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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