Document Detail


Characteristics of Chinese patients with symptomatic Brugada syndrome in Taiwan.
MedLine Citation:
PMID:  12845244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since 1992, the Brugada syndrome has been increasingly recognized worldwide, although its incidence and distribution remain unclear. In Asia, several cases have been reported in Japan, Thailand, Singapore, and Vietnam. However, little information is available from the Chinese population. Since June 1997, we have identified 10 patients with the diagnosis of the Brugada syndrome from six hospitals in Taiwan. All patients were male with the mean age of 46 +/- 7 years (range 36-61). They all had a normal chemistry profile, coronary angiography and echocardiography. Clinical presentations varied from seizure and syncope to sudden cardiac death. MRI and ultrafast CT of the heart did not show any abnormalities. Sustained ventricular tachycardia/ventricular fibrillation (VF) was induced in 7 of 8 patients who underwent an electrophysiologic study. The pharmacological provocation test was positive in 4 of 5 patients. One of the 4 patients who had a genetic study showed SCN5A gene mutation. An implantable cardioverter defibrillator (ICD) was implanted in 8 patients. During a mean follow-up of 29 +/- 17 months (range 2-54), 3 of 8 patients who had an ICD received appropriate ICD discharges after implantation. These 3 patients who were subsequently treated with antiarrhythmic agents have had no further recurrent ICD discharges. Two patients who refused ICD implantation are alive and well without taking antiarrhythmic agents. Our study showed that the clinical characteristics of our patients are similar to those described in the literature and that ICD is an effective treatment modality for patients with recurrent VF. However, antiarrhythmic agents may be beneficial for suppressing arrhythmia recurrences in selected patients.
Authors:
Jyh-Ming Juang; Shoei K Stephen Huang; Chia-Ti Tsai; Fu-Tien Chiang; Jiunn-Lee Lin; Ling-Ping Lai; Chun-Chieh Wang; Chi-Tai Kuo; Kwo-Chang Ueng; Chi-Woon Kong; Wen-Chin Ko; Meng-Huan Lei; Hsuan-Ming Tsao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  99     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2003  
Date Detail:
Created Date:  2003-07-07     Completed Date:  2003-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  182-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Affiliation:
National Taiwan University Hospital, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Arrhythmia Agents / therapeutic use
China / ethnology
Coronary Angiography
Echocardiography, Doppler
Electrocardiography, Ambulatory
Exercise
Exercise Test
Heart Catheterization
Humans
Male
Middle Aged
Polymerase Chain Reaction
Procainamide / therapeutic use
Syndrome
Tachycardia, Ventricular / diagnosis,  ethnology*,  physiopathology*,  therapy
Taiwan
Ventricular Fibrillation / ethnology,  physiopathology
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 51-06-9/Procainamide

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