| Characteristics of antihypertensive medication and change of prescription over 1 year of follow up in Japan: Fukushima Research of Hypertension (FRESH). | |
| | |
MedLine Citation:
|
PMID: 20725053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The relationship between achieving target blood pressures and medication modification among hypertensive patients in Japan is relatively unknown. We examined the incidence of prescription changes and how the prescription changes influence success rates in achieving target blood pressures in a group of patients with uncontrolled hypertension. METHODS: This prospective observational cohort study (July 2006 to May 2007) examined the association between blood pressure control and antihypertensive medication among 2,735 Japanese hypertensive patients who completed four seasonal follow-ups and whose medications were verified. The primary outcome was "therapeutic failure" at the third follow-up survey. Logistic regression analyzed how prescription changes may influence therapeutic failure risk. Common medication changes were estimated using follow-up data. RESULTS: Median ages and proportion of males were 73 years and 43.8% vs. 69 years and 45.6% in those with controlled and those with uncontrolled hypertension at baseline, respectively. At baseline, 1,496 patients were uncontrolled, and 296 (18.0%) changed prescriptions during the follow-up period. Among patients with diabetes mellitus, renal disease, or organ damage and vascular complications, who were uncontrolled at baseline, prescription changes during the year significantly increased therapeutic failures at the third follow-up after adjusting for related variables. About half of the changes at each follow-up visit remained in the same class or combination category. CONCLUSIONS: This study identified infrequent changes in prescription and minor modifications of medication even among uncontrolled hypertension. We highlight the importance of reviewing prescription content to maintain or improve blood pressure levels to achieve recommended treatment goals. |
| | |
Authors:
|
Hirohide Yokokawa; Hironobu Sanada; Aya Goto; Tsuyoshi Watanabe; Robin A Felder; Pedro A Jose; Gilbert M Eisner; Seiji Yasumura |
Related Documents
:
|
10826553 - Hypertension in developing economies: a review of population-based studies carried out ... 15149313 - Differential effects of calcium antagonist subclasses on markers of nephropathy progres... 16626423 - Diurnal variation of ocular hysteresis in normal subjects: relevance in clinical context. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-19 |
Journal Detail:
|
Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-16 Completed Date: 2011-03-03 Revised Date: 2011-06-30 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 1299-305 Citation Subset: IM |
Affiliation:
|
Department of Public Health, Fukushima Medical University School of Medicine, Fukushima, Japan. yokokawa@fmu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiotensin Receptor Antagonists / therapeutic use Antihypertensive Agents / therapeutic use* Calcium Channel Blockers / therapeutic use Drug Prescriptions Female Humans Hypertension / drug therapy* Japan Male Physician's Practice Patterns* Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin Receptor Antagonists; 0/Antihypertensive Agents; 0/Calcium Channel Blockers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sF...
Next Document: Adult hypertension is associated with blood pressure variability in childhood in blacks and whites: ...