| Characteristic behavioral seizures and abnormal signal asymmetry of magnetic resonance imaging in an electrogenic rat model of chronic epilepsy. | |
| | |
MedLine Citation:
|
PMID: 12589409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chronic tetani (60 Hz, 2 s, 0.4~0.6 mA) were administered to the dorsal hippocampus (DHPC) or the medial temporal lobe neocortex (MTNC) of rats, to study the role of the entorhinal cortex (EC)-hippocampal loop in temporal lobe epileptogenesis. This was repeated once a day for 7 or 10 days. Magnification of hyper-intensity was induced by tetanization of the HPC or the MTNC, as detected by contralateral T(2) weighed magnetic resonance imaging (T(2)-WI). The effects were associated with an enlarged volume of the lateral ventricle (LV), which was verified histologically. T(2)-WI hper-intensities, contralateral to the tetanized hemispheres, were observed with high frequency primary wet dog shakes (WEDS) in the DHPC-stimulated rats and with low frequency WEDS in the MTNC-stimulated rats. It seems likely that the same neural mechanisms are shared by chronic tetanization of the right HPC and the righ MTNC, involving the closed EC-HPC loop. Poor correlation between contralateral T(2)-WI hper-intensities and light primary behavioral seizures in the MTNC-stimulated rats might be attributed to a controlled information flow into or out of this loop because of potential EC gating. In addition, asymmetric T(2)-WI hyper-intensities in the LV area reflected a hemispheric dependence, contralateral to the electrogenic focus in our model of rat epilepsy. |
| | |
Authors:
|
D Han; X R Zhang; Y F Tang; M L Liu; S J Yin |
Related Documents
:
|
21264099 - Evaluation of the hypoglycemic activity of cucumis metuliferus (cucurbitaceae) fruit pu... 7522929 - Immunosuppressants and calcineurin inhibitors, cyclosporin a and fk506, reversibly inhi... 12787859 - Influence of hypoosmolality on the blood-brain barrier permeability during epileptic se... 15694919 - Neuropeptide y suppresses absence seizures in a genetic rat model. 8252399 - Long-lasting changes in the origin of spontaneous discharges from amygdala-kindled rats... 17395429 - Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is... 6460069 - Effects of various antiplatelet drugs and defibrinating agent on experimental glomerulo... 2675019 - Reversibility of gnrh agonist-induced inhibition of testicular function: differences be... 2531429 - Course of liver regeneration after partial hepatectomy in rats treated with dialysates ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Sheng li xue bao : [Acta physiologica Sinica] Volume: 53 ISSN: 0371-0874 ISO Abbreviation: Sheng Li Xue Bao Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2003-02-17 Completed Date: 2003-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 20730130R Medline TA: Sheng Li Xue Bao Country: China |
Other Details:
|
Languages: eng Pagination: 224-30 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Medical College, Wuhan University, Wuhan 430071. DanHLiLi@public.wuhan.cngb.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Electric Stimulation Electrodes, Implanted Epilepsy, Temporal Lobe / etiology, physiopathology* Hippocampus / physiopathology* Magnetic Resonance Imaging Male Neocortex / physiopathology* Rats Rats, Sprague-Dawley |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in SR Ca2+-ATPase activity, Ca2+ release and uptake kinetics of diaphragm muscle after diffe...
Next Document: Roles of Galphaq/11 mediated- and platelet-derived growth factor mediated-signal transduction pathwa...