Document Detail

Characteristic alterations of the peritoneum after carbon dioxide pneumoperitoneum.
MedLine Citation:
PMID:  10347302     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Any route of entry into the abdomen contributes to alterations of the intraperitoneal organs with different clinical consequences. Characteristic alterations of the peritoneum after CO2 pneumoperitoneum used in laparoscopic surgery is examined. METHODS: A CO2 pneumoperitoneum with an intraperitoneal pressure of 6 mmHg was applied for 30 min in 32 nude mice. In the course of 4 days, the animals were killed and the peritoneal surface of the abdominal wall was studied by means of scanning electron microscopy. RESULTS: Already 2 h after release of the pneumoperitoneum, mesothelial cells were bulging up. The intercellular clefts thereby increased in size, and the underlying basal lamina became visible. This reaction peaked after 12 h. Subsequently, peritoneal macrophages and lymphocytes filled all gaps, thereby recovering the basal lamina. CONCLUSION: The morphologic integrity of the peritoneum is temporarily disturbed by a CO2 pneumoperitoneum.
J Volz; S Köster; Z Spacek; N Paweletz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical endoscopy     Volume:  13     ISSN:  0930-2794     ISO Abbreviation:  Surg Endosc     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-08     Completed Date:  1999-07-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  611-4     Citation Subset:  IM    
Department of Gynecology and Obstetrics, Universitäts-Klinikum Mannheim, D-68135 Mannheim, Germany.
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MeSH Terms
Carbon Dioxide*
Mice, Nude
Microscopy, Electron, Scanning
Peritoneum / ultrastructure*
Pneumoperitoneum, Artificial*
Reg. No./Substance:
124-38-9/Carbon Dioxide
Comment In:
Surg Endosc. 2001 May;15(5):531   [PMID:  11353984 ]

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