Document Detail

Characteristic alteration in the concentration of IV 3NeuAc alpha-nLc4Cer in the villi of human placenta during the gestational period.
MedLine Citation:
PMID:  8248034     Owner:  NLM     Status:  MEDLINE    
A study on the ganglioside composition in the villi isolated from human placenta at various gestational periods was carried out by conventional procedures including thin-layer chromatography (TLC), TLC-immunostaining, negative ion fast-atom bombardment mass spectrometry (FABMS) and exoglycosidase treatment. The major gangliosides in the villi were II3 NeuAc-LacCer (GM3) and IV3NeuAc alpha-nLc4Cer, comprising 60-70% of the total gangliosides. The concentration of IV3NeuAc alpha-nLc4Cer per gram dry weight of tissue in the villi was found to be gradually decreased from the early to the late gestational period and the molecule with 2-hydroxy fatty acids was undetectable after 20 weeks of the gestational period. However, no significant correlation between the concentration of GM3 and the gestational periods was observed. Thus the characteristic alteration in the concentration of IV3NauAc alpha-nLc4Cer in the villi might be related to various functions of human placental villi during the gestational period.
M Mikami; K Takamatsu; J Tanaka; H Sasaki; M Sakayori; M Iwamori; S Nozawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  14     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1993 Jul-Aug
Date Detail:
Created Date:  1993-12-27     Completed Date:  1993-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  407-16     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Chorionic Villi / metabolism*
Fatty Acids / analysis
G(M1) Ganglioside / chemistry,  metabolism
G(M2) Ganglioside / chemistry,  metabolism
Gangliosides / metabolism*
Gestational Age
Reg. No./Substance:
0/Fatty Acids; 0/Gangliosides; 19600-01-2/G(M2) Ganglioside; 37758-47-7/G(M1) Ganglioside; 97047-95-5/2-3-N-acetylneuraminyl-1-3-galactosyl-1-3-N-acetylglucosyl-1-4-galactosyl-1-glucosylceramide

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