| Characteristic Neuroimaging in Patients with Tumefactive Demyelinating Lesions Exceeding 30 mm. | |
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MedLine Citation:
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PMID: 20572907 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Features of tumefactive demyelinating lesion (TDL) on magnetic resonance imaging (MRI) can facilitate the differential diagnosis of TDL and neoplastic lesions, but vary considerably among patients. The larger TDL grows, the more difficult it becomes to differentiate TDL from neoplastic lesions. The purpose of this study was to elucidate typical MRI features in 12 patients with large TDL (>30 mm in diameter). METHODS: We identified 12 patients with large TDL (six men, six women; age range 17-64 years, median age 27 years) and studied the clinical histories and the results of laboratory and various radiological studies in these patients. All cases of clinically definite multiple sclerosis were diagnosed in accordance with McDonald's revised criteria. RESULTS: Common MRI features of large TDLs included variable degrees of mass effect (71%) and edema (100%), a T2 hypointense rim (79%), venular enhancement (57%), and peripheral restriction on diffusion-weighted images (50%). Ring enhancement (38%), open-ring enhancement (31%), or decreased N-acetylaspartate ratios on magnetic resonance spectroscopy (22%) were less frequently observed. Brain angiography demonstrated venous dilatations on and around the TDL. CONCLUSIONS: The diagnosis of large TDL is challenging. Our findings suggest that multiple venous dilatations on and around TDLs on angiography can facilitate diagnosis. |
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Authors:
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Takao Kiriyama; Hiroshi Kataoka; Toshiaki Taoka; Yasuyo Tonomura; Mari Terashima; Masami Morikawa; Emi Tanizawa; Makoto Kawahara; Yoshiko Furiya; Kazuma Sugie; Kimihiko Kichikawa; Satoshi Ueno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: e69-77 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 by the American Society of Neuroimaging. |
Affiliation:
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From the Department of Neurology (TK, HK, YT, MT, MM, ET, MK, YF, KS, SU); and Radiology (TT, KK), Nara Medical University, Kashihara, Nara, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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