Document Detail


Characterisation of three microsatellite polymorphisms (D21S1262, D21S1419 and D21S1421) from band 21q22.1.
MedLine Citation:
PMID:  7759089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have isolated three clones, containing highly polymorphic CA-repeat sequences, from a human chromosome 21 phage library (LA21NS01). These clones have been localised to band q22.1 by using a chromosome 21 somatic cell hybrid panel. D21S1262 is located between breakpoints 6918-8a1 and 3x2S, and D21S1419 and D21S1421 are localised between breakpoints JC6-A and MRC2G. Their observed heterozygosities range between 0.75 and 0.85 as shown by unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These highly polymorphic markers should be useful for improving the analysis of this region of chromosome 21, which contains important genes such as SOD1, GART and IFNAR.
Authors:
A Bosch; J Guimerà; D Patterson; X Estivill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  95     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-27     Completed Date:  1995-06-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  596-8     Citation Subset:  IM    
Affiliation:
Molecular Genetics Department, Cancer Research Institute (IRO), Hospital Duran i Reynals, Barcelona, Catalunya, Spain.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 21*
DNA, Satellite / chemistry,  genetics*
Genetic Markers
Humans
Hybrid Cells
Molecular Sequence Data
Polymorphism, Genetic / genetics*
Repetitive Sequences, Nucleic Acid / genetics
Grant Support
ID/Acronym/Agency:
HD17449/HD/NICHD NIH HHS; HG00716/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Satellite; 0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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