Document Detail

Characterisation of rotavirus causing acute diarrhea in children in Kathmandu, Nepal ; dominance of G12.
MedLine Citation:
PMID:  23038804     Owner:  NLM     Status:  Publisher    
Diarrheal diseases are major problem of developing countries. Though precise data on childhood mortality associated with diarrheal diseases in Nepal is not available, it has been estimated that approximately 25% of child death are associated with diarrheal disease, particularly acute diarrhea. The purpose of this study was to assess the incidence of rotavirus causing acute diarrhea in children under 5 years of age. A total of 525 children with acute diarrhea in a children's hospital of Kathmandu, Nepal were enrolled between April 2011 to September 2011. The incidence of acute diarrhea due to rotavirus was 25.9% (136/525) by ELISA. The percentage of rotavirus infected male were higher 64.5% than female 35.5%. The frequency of rotavirus cases were higher in the children below 2 years of age among which the highest case 80.2% were found in age between 6-24 months (P<0.01). The genotypic characterization by reverse-transcriptase polymerase chain reaction(RT-PCR) revealed that the serotype G12 represented 55.9% in this study associated with P-types either P[6], P[4] or P[8]. Further a total of eight G/P combination were identified, with G12P[6] 46.4% being the most common strain type of rotavirus in Nepal.
Shamshul Ansari; Jeevan Bahadur Sherchand; Bharat Mani Pokhrel; Basista Prasad Rijal; Keshav Prasad Parajuli; Shyam Kumar Mishra; Rajan Kumar Dahal; Sovita Shrestha; Sarmila Tandukar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Journal of medical microbiology     Volume:  -     ISSN:  1473-5644     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu;
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