Document Detail


Characterisation of the nuclear receptors FXR, PXR and CAR in normal and cholestatic placenta.
MedLine Citation:
PMID:  21596433     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bile acids are the toxic end products of hepatic cholesterol metabolism. They are synthesised from early in gestation and excreted via the placenta. The mechanism for transplacental excretion of bile acids is not known. The gene and protein expression of the nuclear receptors responsible for hepatic bile acid metabolism and transport was studied in eight normal and fourteen cholestatic placentas, and in an ex vivo model. The expression of the nuclear receptor FXR and several of it's target genes and of PXR and CAR was found to be very low in both normal and cholestatic placenta.
Authors:
V L Geenes; P H Dixon; J Chambers; S Raguz; J J G Marin; K K Bhakoo; C Williamson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-17
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK; MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK.
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