Document Detail


Characterisation of methicillin resistant S. aureus strains and risk factors for acquisition in a teaching hospital in northeast India.
MedLine Citation:
PMID:  20404458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: A point prevalence study was carried out in a teaching hospital in Assam to characterise S. aureus strains, establish the rate of colonisation of methicillin resistant S. aureus (MRSA) and associated risk factors for its acquisition. MATERIALS AND METHODS: Antibiogram-Resistogram profile was done by BSAC standardized disc sensitivity method; Phage and RFLP typing were carried out by the PHLS, London. RESULTS: Single MRSA strain resistant to multiple classes of anti-staphylococcal antibiotics dominated the hospital. The MRSA colonisation rate was found to be 34% (n=29) and 18% (n=80) in orthopaedics and surgery, respectively and only approximately 1% (n=73) in the medical units. Exposure to ciprofloxacin and surgery were risk factors but duration of hospital stay was not. In contrast, methicillin sensitive S. aureus (MSSA) strains were usually distinct strains and sensitive to most of the anti-staphylococcal antibiotics including 18% to penicillin. CONCLUSIONS: The MRSA strain prevalent in the hospital phenotypically resembles the predominant Asian strain viz., Brazilian/Hungarian strains (CC8-MRSA-III). Duration was not a risk factor, which suggests that in absence of exposure to specific antimicrobials, even in a hospital with no or little infection control intervention, a vast majority remain free from MRSA. This underlines the importance of rational prescribing empirical antibiotics.
Authors:
J B Sarma; G U Ahmed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of medical microbiology     Volume:  28     ISSN:  1998-3646     ISO Abbreviation:  Indian J Med Microbiol     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700903     Medline TA:  Indian J Med Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  127-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Northumbria Healthcare NHS Foundation Trust, Newcastle-Upon-Tyne, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bacterial Typing Techniques
Bacteriophage Typing
Cross Infection / epidemiology*,  microbiology*
DNA Fingerprinting
Genotype
Hospitals, Teaching
Humans
India / epidemiology
Male
Methicillin-Resistant Staphylococcus aureus / classification*,  drug effects,  genetics,  isolation & purification*
Microbial Sensitivity Tests
Molecular Epidemiology
Phenotype
Polymorphism, Restriction Fragment Length
Prevalence
Risk Factors
Staphylococcal Infections / epidemiology*,  microbiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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