Document Detail

Characterisation of hemolysis induced by T-2 toxin.
MedLine Citation:
PMID:  3970969     Owner:  NLM     Status:  MEDLINE    
The erythrocyte constitutes a good model system for the study of membrane-associated toxicity events caused by the trichothecene mycotoxin, T-2. This study confirms that T-2 has a direct lytic effect on erythrocytes. Lysis of guinea pig red cells requires approx. 10(10) molecules/cell and reaches plateau values after 4-6 h. An activation energy, Ea approximately equal to 4.5 kcal was derived from the Arrhenius equation. By use of osmotic blockers of differing Stokes' radii, the functional size of the membrane lesion caused by T-2 toxin was shown to be smaller than 5.5 A. It is concluded that T-2 toxin may exert its toxic effects via the cell membrane.
M I Gyongyossy-Issa; V Khanna; G G Khachatourians
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  838     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-03-29     Completed Date:  1985-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  252-6     Citation Subset:  IM    
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MeSH Terms
Carbohydrates / pharmacology
Dose-Response Relationship, Drug
Osmosis / drug effects
Sesquiterpenes / pharmacology*
T-2 Toxin / pharmacology*
Time Factors
Reg. No./Substance:
0/Carbohydrates; 0/Sesquiterpenes; 21259-20-1/T-2 Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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