| Characterisation and functionality of inhalation anhydrous lactose. | |
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MedLine Citation:
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PMID: 20100552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationships between the physicochemical properties and functionality in dry powder inhaler (DPI) performance was investigated for inhalation grade anhydrous lactose and compared to monohydrate grades. The excipients were characterised using a range of techniques including particle size analysis, moisture sorption and powder rheometry. The inhalation anhydrous lactose grades were readily characterisable. The aerosolisation performance of capsule based DPI formulations containing budesonide (200microg) and different grades of lactose evaluated using inertial impaction measurements produced fine particle doses of budesonide ranging from 24 to 49microg. There were no apparent relationships between aerosolisation performance and excipient characteristics, such as particle size and powder density. However, formulations containing lactose grades which exhibit higher powder fluidisation energy values resulted in higher fine particle doses of budesonide. |
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Authors:
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Chonladda Pitchayajittipong; Robert Price; Jagdeep Shur; J Sebastian Kaerger; Stephen Edge |
Publication Detail:
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Type: Journal Article Date: 2010-01-25 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 390 ISSN: 1873-3476 ISO Abbreviation: Int J Pharm Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-13 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 134-41 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Pharmaceutical Surface Science Research Group, School of Pharmacy and Pharmacology, University of Bath, Bath, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aerosols / chemistry* Budesonide / chemistry Drug Compounding / methods* Excipients / chemistry Lactose / chemistry* Particle Size Physicochemical Processes Powders / chemistry Rheology Surface Properties Water / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Excipients; 0/Powders; 51333-22-3/Budesonide; 63-42-3/Lactose; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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