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Chapter 9 protein arginine methyltransferases nuclear receptor coregulators and beyond.
MedLine Citation:
PMID:  20374708     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Protein arginine methyltransferases (PRMTs) are a family of enzymes that play a crucial role in diverse cellular functions. Several PRMTs have been associated with gene expression regulation, in which PRMTs act as histone methyltransferases, secondary coregulators of transcription, or facilitate mRNA splicing and stability. Additional functions include modulation of protein localization, ribosomal assembly, and signal transduction. At the organismal level, several PRMTs appear to be important for development and may play an important role in cancer. The relationships between their cellular and organismal functions are poorly understood; at least in part due to the large body of enzymatic substrates for PRMTs and their transcriptional targets that remain to be determined. Specific PRMT inhibitors have been developed in recent years, which should help to shed light on their diverse biological roles. Connecting PRMT cellular functions with their global effects on an organism will facilitate development of novel treatments for human diseases.
Authors:
Peter Kuhn; Wei Xu
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Publication Detail:
Type:  Journal Article     Date:  2009-10-07
Journal Detail:
Title:  Progress in molecular biology and translational science     Volume:  87     ISSN:  1877-1173     ISO Abbreviation:  Prog Mol Biol Transl Sci     Publication Date:  2009  
Date Detail:
Created Date:  2010-04-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101498165     Medline TA:  Prog Mol Biol Transl Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  299-342     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Inc. All rights reserved.
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